Evidence map›Paper›PMID 36982742›Full record

ArticleInternational journal of molecular sciences2023

The Influence of Prenatal Exposure to Methamphetamine on the Development of Dopaminergic Neurons in the Ventral Midbrain.

Walaa F Alsanie, Sherin Abdelrahman, Raed I Felimban, Heba A Alkhatabi, Ahmed Gaber, Ebtisam Abdulah Alosimi, Majid Alhomrani, Hamza Habeeballah, Charlotte A E Hauser, Abdulhakeem S Alamri and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Walaa F AlsanieDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Sherin AbdelrahmanLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia.ORCID 0000-0002-9653-7640
Raed I FelimbanDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-0853-2162
Heba A AlkhatabiDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ahmed GaberCentre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0002-8297-935X
Ebtisam Abdulah AlosimiCentre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Taif 21944, Saudi Arabia.
Majid AlhomraniDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0001-9798-0962
Hamza HabeeballahDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences in Rabigh, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-0116-3701
Charlotte A E HauserLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia.
Abdulhakeem S AlamriDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0003-3174-0434
Aiysha AlthobaitiCentre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Taif 21944, Saudi Arabia.
Abdulaziz AlsharifDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Ahmed S AlzahraniCentre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Taif 21944, Saudi Arabia.
Mohammad S Al-GhamdiDepartment of Clinical Laboratories Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Bassem M RaafatDepartment of Radiological Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Khaled A AlswatDepartment of Internal Medicine, School of Medicine, Taif University, Taif 21944, Saudi Arabia.
Yusuf S AlthobaitiDepartment of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0003-3128-2824
Yousif A AsiriDepartment of Clinical Pharmacy, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia.
Taif University · SAKing Abdulaziz University · SAKing Abdullah University of Science and Technology · SA

Funding

Deputyship for Research and Innovation, Ministry of Education, Saudi Arabia. 1-441-133
6 · The paper itself

Abstract

Methamphetamine, a highly addictive central nervous system (CNS) stimulant, is used worldwide as an anorexiant and attention enhancer. Methamphetamine use during pregnancy, even at therapeutic doses, may harm fetal development. Here, we examined whether exposure to methamphetamine affects the morphogenesis and diversity of ventral midbrain dopaminergic neurons (VMDNs). The effects of methamphetamine on morphogenesis, viability, the release of mediator chemicals (such as ATP), and the expression of genes involved in neurogenesis were evaluated using VMDNs isolated from the embryos of timed-mated mice on embryonic day 12.5. We demonstrated that methamphetamine (10 µM; equivalent to its therapeutic dose) did not affect the viability and morphogenesis of VMDNs, but it reduced the ATP release negligibly. It significantly downregulated

Indexed as

Central Nervous System StimulantsMethamphetaminePrenatal Exposure Delayed EffectsAdenosine TriphosphateAnimalsCell DifferentiationDopaminergic NeuronsFemaleHumansMesencephalonMiceTranscription FactorsAdenosine TriphosphateCentral Nervous System StimulantsMethamphetamineTranscription Factorsdopaminergic neuronsembryonic neuronsfetal neurodevelopmentmethamphetamineventral midbrain

Identifiers

PMID36982742
PMCPMC10056332
OpenAlexW4327601324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.