Evidence map›Paper›PMID 36982735›Full record

ArticleInternational journal of molecular sciences2023

PD-1/PD-L1 Control of Antigen-Specifically Activated CD4 T-Cells of Neonates.

Christiane Majer, Holger Lingel, Aditya Arra, Hans-Gert Heuft, Dirk Bretschneider, Silke Balk, Katrin Vogel, Monika C Brunner-Weinzierl

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Research progress on T-cell responses inFrontiers in microbiology · 2026
    Pooled it
  2. Review
  3. Article
  4. Neonatal Immunology.International journal of molecular sciences · 2024
    Article
  5. Cytokine Storm Related to CD4Immune network · 2024
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Christiane MajerDepartment of Experimental Pediatrics, Medical Faculty, Otto-von-Guericke-University, 39120 Magdeburg, Germany.ORCID 0000-0002-3521-1460
Holger LingelDepartment of Experimental Pediatrics, Medical Faculty, Otto-von-Guericke-University, 39120 Magdeburg, Germany.ORCID 0000-0002-3407-8610
Aditya ArraDepartment of Experimental Pediatrics, Medical Faculty, Otto-von-Guericke-University, 39120 Magdeburg, Germany.
Hans-Gert HeuftInstitute of Transfusion Medicine and Immunohematology, Medical Faculty, Otto-von-Guericke-University, 39120 Magdeburg, Germany.
Dirk BretschneiderMaternity Clinic, Hospital Sankt Marienstift, 39110 Magdeburg, Germany.
Silke BalkDepartment of Experimental Pediatrics, Medical Faculty, Otto-von-Guericke-University, 39120 Magdeburg, Germany.
Katrin VogelDepartment of Experimental Pediatrics, Medical Faculty, Otto-von-Guericke-University, 39120 Magdeburg, Germany.
Monika C Brunner-WeinzierlDepartment of Experimental Pediatrics, Medical Faculty, Otto-von-Guericke-University, 39120 Magdeburg, Germany.ORCID 0000-0002-6838-3568
Otto-von-Guericke-Universität Magdeburg · DE

Funding

BMBF (Bundesministerium für Bildung und Forschung) LongCoCID - 01EP2101CDeutsche Forschungsgemeinschaft (DFG) Br1860-12/1
6 · The paper itself

Abstract

Newborns are highly susceptible to infections; however, the underlying mechanisms that regulate the anti-microbial T-helper cells shortly after birth remain incompletely understood. To address neonatal antigen-specific human T-cell responses against bacteria,

Indexed as

CD4-Positive T-LymphocytesProgrammed Cell Death 1 ReceptorAdultAntigensB7-H1 AntigenHumansInfant, NewbornStaphylococcus aureusT-Lymphocytes, Helper-InducerAntigensB7-H1 AntigenProgrammed Cell Death 1 ReceptorbacteriaCD4 T cellimmune checkpoint moleculenewbornPD-1/PD-L1pediatric immunologyStaphylococcus aureus (S. aureus)staphylococcus enterotoxin B (SEB)T-helper cells

Identifiers

PMID36982735
PMCPMC10051326
OpenAlexW4327620698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.