Evidence map›Paper›PMID 36982703›Full record

ArticleInternational journal of molecular sciences2023

Irradiation-Induced Dysbiosis: The Compounding Effect of High-Fat Diet on Metabolic and Immune Functions in Mice.

Briana K Clifford, Nadia M L Amorim, Nadeem O Kaakoush, Lykke Boysen, Nicodemus Tedla, David Goldstein, Edna C Hardeman, David Simar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Briana K CliffordSchool of Health Sciences, UNSW, Sydney, NSW 2052, Australia.
Nadia M L AmorimUTS Centenary Centre for Inflammation, School of Life Sciences, University of Technology, Sydney, NSW 2050, Australia.ORCID 0000-0002-3619-7410
Nadeem O KaakoushSchool of Biomedical Sciences, UNSW, Sydney, NSW 2052, Australia.
Lykke BoysenSchool of Health Sciences, UNSW, Sydney, NSW 2052, Australia.ORCID 0000-0002-9377-8342
Nicodemus TedlaSchool of Biomedical Sciences, UNSW, Sydney, NSW 2052, Australia.
David GoldsteinPrince of Wales Clinical School, UNSW, Sydney, NSW 2052, Australia.ORCID 0000-0001-6142-3291
Edna C HardemanSchool of Biomedical Sciences, UNSW, Sydney, NSW 2052, Australia.
David SimarSchool of Health Sciences, UNSW, Sydney, NSW 2052, Australia.ORCID 0000-0002-3862-1932

Funding

Cancer Council New South Wales RG 13-17
6 · The paper itself

Abstract

The negative impact of irradiation or diet on the metabolic and immune profiles of cancer survivors have been previously demonstrated. The gut microbiota plays a critical role in regulating these functions and is highly sensitive to cancer therapies. The aim of this study was to investigate the effect of irradiation and diet on the gut microbiota and metabolic or immune functions. We exposed C57Bl/6J mice to a single dose of 6 Gy radiation and after 5 weeks, fed them a chow or high-fat diet (HFD) for 12 weeks. We characterised their faecal microbiota, metabolic (whole body and adipose tissue) functions, and systemic (multiplex cytokine, chemokine assay, and immune cell profiling) and adipose tissue inflammatory profiles (immune cell profiling). At the end of the study, we observed a compounding effect of irradiation and diet on the metabolic and immune profiles of adipose tissue, with exposed mice fed a HFD displaying a greater inflammatory signature and impaired metabolism. Mice fed a HFD also showed altered microbiota, irrespective of irradiation status. An altered diet may exacerbate the detrimental effects of irradiation on both the metabolic and inflammatory profiles. This could have implications for the diagnosis and prevention of metabolic complications in cancer survivors exposed to radiation.

Indexed as

Diet, High-FatGastrointestinal MicrobiomeAnimalsCytokinesDysbiosisImmunityMiceMice, Inbred C57BLCytokinesadipogenesisdysbiosisgut microbiotahigh-fat dietinflammationinsulin resistanceirradiation

Identifiers

PMID36982703
PMCPMC10057711

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.