Evidence map›Paper›PMID 36982658›Full record

ArticleInternational journal of molecular sciences2023

Associations of Biopterins and ADMA with Vascular Function in Peripheral Microcirculation from Patients with Chronic Kidney Disease.

Samsul Arefin, Lars Löfgren, Peter Stenvinkel, Anna B Granqvist, Karolina Kublickiene

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Samsul ArefinDepartment of Clinical Science, Intervention & Technology, Division of Renal Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.ORCID 0000-0002-8050-9100
Lars LöfgrenEarly CVRM, BioPharmaceuticals R&D, AstraZeneca, 431 50 Mölndal, Sweden.
Peter StenvinkelDepartment of Clinical Science, Intervention & Technology, Division of Renal Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.ORCID 0000-0002-8785-4820
Anna B GranqvistEarly CVRM, BioPharmaceuticals R&D, AstraZeneca, 431 50 Mölndal, Sweden.
Karolina KublickieneDepartment of Clinical Science, Intervention & Technology, Division of Renal Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden.ORCID 0000-0002-4841-6836
Karolinska Institutet · SEAstraZeneca (Sweden) · SE

Funding

ALF PSAstraZeneca ABG, LLCIMED 2020Hjärt lungfonden PSNjurfonden 2018Vetenskapsrådet 2018-00932 GOING-FWD
6 · The paper itself

Abstract

We hypothesized that patients with chronic kidney disease (CKD) display an altered plasma amino acid (AA) metabolomic profile that could contribute to abnormal vascular maintenance of peripheral circulation in uremia. The relationships between plasma AAs and endothelial and vascular smooth muscle function in the microcirculation of CKD patients are not well understood. The objective of this study is to investigate to what extent the levels of AAs and its metabolites are changed in CKD patients and to test their relationship with endothelial and vascular smooth muscle function. Patients with CKD stages 3 and 5 and non-CKD controls are included in this study. We report that there was a significant reduction of the biopterin (BH

Indexed as

Renal Insufficiency, ChronicUremiaArginineBiopterinsCitrullineEndothelium, VascularHumansMicrocirculationArginineBiopterinsCitrullineN,N-dimethylarginineamino acidsasymmetric dimethylargininebiopterinschronic kidney diseasevascular function

Identifiers

PMID36982658
PMCPMC10056709
OpenAlexW4324382277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.