Evidence map›Paper›PMID 36982624›Full record

ArticleInternational journal of molecular sciences2023

The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022.

Gary H Perdew, Charlotte Esser, Megan Snyder, David H Sherr, Ellen H van den Bogaard, Karen McGovern, Pedro M Fernández-Salguero, Xavier Coumoul, Andrew D Patterson

Open access · goldAbstract readConference Proceedings
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 5 countries.

Gary H PerdewDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA.
Charlotte EsserIUF-Leibniz Research Institute for Environmental Medicine, Auf'm Hennekamp 50, 40225 Düsseldorf, Germany.
Megan SnyderDepartment of Environmental Health, Boston University School of Public Health, 72 East Concord Street, Boston, MA 02118, USA.ORCID 0000-0002-7893-3228
David H SherrDepartment of Environmental Health, Boston University School of Public Health, 72 East Concord Street, Boston, MA 02118, USA.ORCID 0000-0003-3353-0553
Ellen H van den BogaardDepartment of Dermatology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Karen McGovernIkena Oncology, Inc., 645 Summer Street Suite 101, Boston, MA 02210, USA.
Pedro M Fernández-SalgueroDepartamento de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Extremadura, Avenida de Elvas s/n, 06071 Badajoz, Spain.ORCID 0000-0003-2839-5027
Xavier CoumoulINSERM UMR-S1124, 45 rue des Saints-Peères, 75006 Paris, France.ORCID 0000-0003-2928-9648
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA 16802, USA.ORCID 0000-0003-2073-0070
Boston University · USPennsylvania State University · USInserm · FRKura Oncology (United States) · USLeibniz Institute of Environmental Medicine · DERadboud University Nijmegen · NLUniversidad de Extremadura · ES

Funding

Activation of the Ah receptor and epithelial integrityR35ES028244 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2017 to 2024
$6.2M
AHR-mediated immunosuppression in glioblastomaR01ES029136 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI Francisco J. Quintana, DAVID A REARDON · 2019 to 2026
$3.3M
Environmental Ah Receptor Ligand Impact on the Host-Microbiome Metabolic AxisR01ES028288 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2021
$1.7M
An Environmental Chemical Receptor, the AhR, as a Mediator of Multiple Immune Checkpoints in Oral CancerR01ES033692 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SHERR, DAVID H · 2022 to 2024
$1.4M
Acquisition of an Orbitrap Fusion Lumos Tribid Mass Spectrometer to Accelerate Metabolite Identification and Pathway AnalysisS10OD021750 · OD · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2017 to 2017
$966k
Endogenous and Environmental AHR Ligands in Head and Neck Cancer Aggression and ImmunosuppressionR21ES029624 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SHERR, DAVID H · 2019 to 2020
$454k
NIEHS NIH HHS ES028244NIEHS NIH HHS ES028288NIEHS NIH HHS R01 ES028288NIEHS NIH HHS R01 ES029136NIEHS NIH HHS R01 ES033692NIEHS NIH HHS R21 ES029624NIEHS NIH HHS R35 ES028244NIH HHS S10 OD021750
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the list of AHR ligands of microbial, diet, and host metabolism origin continues to grow and has provided important clues as to the function of this enigmatic receptor. The AHR has now been shown to be directly involved in numerous biochemical pathways that influence host homeostasis, chronic disease development, and responses to toxic insults. As this field of study has continued to grow, it has become apparent that the AHR is an important novel target for cancer, metabolic diseases, skin conditions, and autoimmune disease. This meeting attempted to cover the scope of basic and applied research being performed to address possible applications of our basic knowledge of this receptor on therapeutic outcomes.

Indexed as

Autoimmune DiseasesNeoplasmsDietHumansReceptors, Aryl HydrocarbonUniversitiesReceptors, Aryl HydrocarbonAh receptorAHR structurearyl hydrocarbon receptorcancerclinical trialshematopoiesisimmune checkpoint inhibitorintestinal bowel diseasemicrobiomemultiple sclerosisOCT4skin barriersteatosis

Identifiers

PMID36982624
PMCPMC10058801
OpenAlexW4324143405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.