Evidence map›Paper›PMID 36982580›Full record

ArticleInternational journal of molecular sciences2023

Genome-Wide Analysis of Antigen 43 (Ag43) Variants: New Insights in Their Diversity, Distribution and Prevalence in Bacteria.

Valentin Ageorges, Ivan Wawrzyniak, Philippe Ruiz, Cédric Bicep, Mohamed A Zorgani, Jason J Paxman, Begoña Heras, Ian R Henderson, Sabine Leroy, Xavier Bailly and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Genomic dissection ofISME communications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Valentin AgeorgesINRAE, UCA, UMR0454 MEDIS, 63000 Clermont-Ferrand, France.ORCID 0000-0002-6806-9712
Ivan WawrzyniakUCA, CNRS, UMR6023 LMGE, 63000 Clermont-Ferrand, France.ORCID 0000-0002-5362-6117
Philippe RuizINRAE, UCA, UMR0454 MEDIS, 63000 Clermont-Ferrand, France.ORCID 0000-0002-5149-9775
Cédric BicepUCA, CNRS, UMR6023 LMGE, 63000 Clermont-Ferrand, France.
Mohamed A ZorganiINRAE, UCA, UMR0454 MEDIS, 63000 Clermont-Ferrand, France.
Jason J PaxmanDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia.ORCID 0000-0002-1418-5910
Begoña HerasDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia.
Ian R HendersonInstitute for Molecular Biosciences, University of Queensland, St. Lucia, QLD 4067, Australia.
Sabine LeroyINRAE, UCA, UMR0454 MEDIS, 63000 Clermont-Ferrand, France.
Xavier BaillyINRAE, UCA, VetAgro Sup, UMR0346 EPIA, 63122 Saint Genes Champanelle, France.
Panagiotis SapountzisINRAE, UCA, UMR0454 MEDIS, 63000 Clermont-Ferrand, France.ORCID 0000-0001-6286-3918
Eric PeyretailladeUCA, CNRS, UMR6023 LMGE, 63000 Clermont-Ferrand, France.
Mickaël DesvauxINRAE, UCA, UMR0454 MEDIS, 63000 Clermont-Ferrand, France.ORCID 0000-0003-2986-6417

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Antigen 43 (Ag43) expression induces aggregation and biofilm formation that has consequences for bacterial colonisation and infection. Ag43 is secreted through the Type 5 subtype "a" secretion system (T5aSS) and is a prototypical member of the family of self-associating autotransporters (SAATs). As a T5aSS protein, Ag43 has a modular architecture comprised of (i) a signal peptide, (ii) a passenger domain that can be subdivided into three subdomains (SL, EJ, and BL), (iii) an autochaperone (AC) domain, and (iv) an outer membrane translocator. The cell-surface SL subdomain is directly involved in the "Velcro-handshake" mechanism resulting in bacterial autoaggregation. Ag43 is considered to have a ubiquitous distribution in

Indexed as

Escherichia coliEscherichia coli ProteinsAdhesins, Escherichia coliBacterial Outer Membrane ProteinsPhylogenyPrevalenceAdhesins, Escherichia coliBacterial Outer Membrane ProteinsEscherichia coli Proteinsaggregationautotransporterbacterial colonisation and infection and infectionbacterial pathogenscell surface proteinEscherichia coligene diversityphylogenyprotein secretionType V protein secretion system (T5SS)

Identifiers

PMID36982580
PMCPMC10058404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.