Evidence map›Paper›PMID 36982548›Full record

ReviewInternational journal of molecular sciences2023

Enhancing Targeted Therapy in Breast Cancer by Ultrasound-Responsive Nanocarriers.

Isaiah A Edwards, Flavia De Carlo, Juliana Sitta, William Varner, Candace M Howard, Pier Paolo Claudio

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Isaiah A EdwardsDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Flavia De CarloDepartment of Pharmacology and Toxicology, Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Juliana SittaDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0002-6585-8433
William VarnerDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Candace M HowardDepartment of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-6537-3551
Pier Paolo ClaudioDepartment of Pharmacology and Toxicology, Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.ORCID 0000-0001-7790-1622
Jackson Memorial Hospital · USUniversity of Mississippi Medical Center · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

Currently, the response to cancer treatments is highly variable, and severe side effects and toxicity are experienced by patients receiving high doses of chemotherapy, such as those diagnosed with triple-negative breast cancer. The main goal of researchers and clinicians is to develop new effective treatments that will be able to specifically target and kill tumor cells by employing the minimum doses of drugs exerting a therapeutic effect. Despite the development of new formulations that overall can increase the drugs' pharmacokinetics, and that are specifically designed to bind overexpressed molecules on cancer cells and achieve active targeting of the tumor, the desired clinical outcome has not been reached yet. In this review, we will discuss the current classification and standard of care for breast cancer, the application of nanomedicine, and ultrasound-responsive biocompatible carriers (micro/nanobubbles, liposomes, micelles, polymeric nanoparticles, and nanodroplets/nanoemulsions) employed in preclinical studies to target and enhance the delivery of drugs and genes to breast cancer.

Indexed as

Antineoplastic AgentsBreast NeoplasmsNanoparticlesDrug CarriersDrug Delivery SystemsFemaleHumansLiposomesMicellesAntineoplastic AgentsDrug CarriersLiposomesMicellesbreast cancerenhanced targeted therapyultrasoundultrasound-sensitive carriers

Identifiers

PMID36982548
PMCPMC10053544
OpenAlexW4324148863

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.