Evidence map›Paper›PMID 36982525›Full record

ArticleInternational journal of molecular sciences2023

Lifetime Evaluation of Left Ventricular Structure and Function in Male C57BL/6J Mice after Gamma and Space-Type Radiation Exposure.

Agnieszka Brojakowska, Cedric J Jackson, Malik Bisserier, Mary K Khlgatian, Cynthia Grano, Steve R Blattnig, Shihong Zhang, Kenneth M Fish, Vadim Chepurko, Elena Chepurko and 7 more

Open access · goldFull text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Agnieszka BrojakowskaCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-7319-9685
Cedric J JacksonNational Institute of Aerospace, Hampton, VA 23666, USA.ORCID 0009-0008-1400-3284
Malik BisserierDepartment of Cell Biology and Anatomy and Physiology, New York Medical College, Valhalla, NY 10595, USA.ORCID 0000-0001-8826-4649
Mary K KhlgatianCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cynthia GranoCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Steve R BlattnigNational Aeronautics and Space Administration, Hampton, VA 23669, USA.
Shihong ZhangCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kenneth M FishCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Vadim ChepurkoCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Elena ChepurkoCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Virginia GillespieCenter for Comparative Medicine and Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ying DaiCenter for Comparative Medicine and Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Brooke LeeDepartment of Emergency Medicine, Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Venkata Naga Srikanth GarikipatiDepartment of Emergency Medicine, Dorothy M. Davis Heart Lung and Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Lahouaria HadriCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-8108-7993
Raj KishoreDepartment of Cardiovascular Sciences, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.ORCID 0000-0002-8168-3004
David A GoukassianCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Icahn School of Medicine at Mount Sinai · USThe Ohio State University Wexner Medical Center · USNational Aeronautics and Space Administration · USNational Institute of Aerospace · USNew York Medical College · USTemple University · US

Funding

TRAINING PROGRAM IN MOLECULAR AND CELLULAR CARDIOLOGYT32HL007824 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GELB, BRUCE D · 1995 to 2022
$8.6M
The Chromatin Remodeling Factor ARID1a and the Epigenetic Landscape In Pulmonary Arterial HypertensionR01HL173203 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Lahouaria HADRI · 2024 to 2026
$2.5M
Interactions of SERCA2a and BMPRII in Vascular DiseaseR01HL133554 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HADRI, LAHOUARIA · 2016 to 2020
$2.3M
Role of Epac1 in the Pathogenesis of Pulmonary FibrosisR01HL158998 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Lahouaria HADRI · 2022 to 2026
$2.1M
ARID1a and Chromatin Landscape in Pulmonary Vascular DiseaseR03TR004673 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HADRI, LAHOUARIA · 2023 to 2023
$169k
NASA 80NSSC19K1079 (formerly, 80NSSC18K0921)NCATS NIH HHS R03 TR004673NHLBI NIH HHS R01 HL133554NHLBI NIH HHS R01 HL158998NHLBI NIH HHS R01 HL173203NHLBI NIH HHS T32 HL007824
6 · The paper itself

Abstract

The lifetime effects of space irradiation (IR) on left ventricular (LV) function are unknown. The cardiac effects induced by space-type IR, specifically 5-ion simplified galactic cosmic ray simulation (simGCRsim), are yet to be discovered. Three-month-old, age-matched, male C57BL/6J mice were irradiated with

Indexed as

CardiomyopathiesRadiation ExposureAnimalsFibrosisInflammationMaleMiceMice, Inbred C57BLTravelVentricular Function, LeftVentricular Remodelingbiomarkerscardiovascular diseaseechocardiographyionizing space radiationmathematical modeling

Identifiers

PMID36982525
PMCPMC10049327
OpenAlexW4324056860

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read128
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.