Evidence map›Paper›PMID 36982517›Full record

ReviewInternational journal of molecular sciences2023

Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies.

Rita Y P da Silva, Danielle L B de Menezes, Verônica da S Oliveira, Attilio Converti, Ádley A N de Lima

Open access · goldFull text readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
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  11. Chitosan Nanoparticles Entrapping AqueousPlants (Basel, Switzerland) · 2025
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Rita Y P da SilvaDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.ORCID 0000-0001-7322-2016
Danielle L B de MenezesDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.
Verônica da S OliveiraDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.
Attilio ConvertiDepartment of Civil, Chemical and Environment Engineering, Pole of Chemical Engineering, University of Genoa, I-16145 Genoa, Italy.ORCID 0000-0003-2488-6080
Ádley A N de LimaDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, RN, Brazil.ORCID 0000-0002-3798-3915
Universidade Federal do Rio Grande do Norte · BRUniversity of Genoa · IT

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 01
6 · The paper itself

Abstract

Microparticulate systems such as microparticles, microspheres, microcapsules or any particle in a micrometer scale (usually of 1-1000 µm) are widely used as drug delivery systems, because they offer higher therapeutic and diagnostic performance compared to conventional drug delivery forms. These systems can be manufactured with many raw materials, especially polymers, most of which have been effective in improving the physicochemical properties and biological activities of active compounds. This review will focus on the in vivo and in vitro application in the last decade (2012 to 2022) of different active pharmaceutical ingredients microencapsulated in polymeric or lipid matrices, the main formulation factors (excipients and techniques) and mostly their biological activities, with the aim of introducing and discussing the potential applicability of microparticulate systems in the pharmaceutical field.

Indexed as

Drug Delivery SystemsPolymersCapsulesDrug CompoundingExcipientsMicrospheresParticle SizeCapsulesExcipientsPolymersbiological activitydrug delivery systemsin vitro assayin vivo assaypolymeric microparticles

Identifiers

PMID36982517
PMCPMC10049314
OpenAlexW4324057048

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read72
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.