ReviewInternational journal of molecular sciences2023
Chronic Pain-Associated Cardiovascular Disease: The Role of Sympathetic Nerve Activity.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Are adults with chronic pain more likely to develop hypertension than adults without chronic pain? A systematic review and meta-analysis.British journal of anaesthesia · 2025Pooled it
- Expectations and communication in opioid pain management: a qualitative study of patients' experience.Scandinavian journal of primary health care · 2026Article
- Can Chronic Pain Accelerate Chronic Kidney Disease? Is Pain a Disease Modifier Rather than a Symptom?Life (Basel, Switzerland) · 2026Article
- Association of musculoskeletal pain with incidence and recurrence of cardiovascular disease: a longitudinal cohort in China.BMC public health · 2026Article
- Review
- Misguided medical insurance and government policies in the opioid epidemic: A chart review and NARX score analysis.The International journal of risk & safety in medicine · 2026Article
- Factors influencing early postoperative blood pressure goal achievement after endovascular repair for type B aortic dissection: development of a refined nursing monitoring protocol.Frontiers in cardiovascular medicine · 2026Article
- Neuro-immune-bone axis in post-traumatic bone regeneration: temporal regulation, dysregulation mechanisms, and therapeutic implications.Frontiers in immunology · 2026Review
- Chronic Pain in Elderly Patients: Pathophysiology, Pharmacologic and Non-Pharmacologic Therapies, and Interventional Management.Clinical pharmacology : advances and applications · 2026Review
- Article
- Decoding chronic pain: integrating genetics, neuroimaging, and AI for precision management.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Article
- Targeting Inflammatory Pathways in Chronic Low Back Pain: Opportunities for Novel Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Impact of dynamic changes in pain on cardiovascular disease in Chinese middle and elderly people: results from China Health and Retirement Longitudinal Study (CHARLS).BMC public health · 2025Article
- Plasma ALKAL2 levels are associated with coronary atherosclerosis in patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2025Article
- Assessment of Quality of Life Among Patients Experiencing Pain: A Cross-Sectional Study at King Abdullah Medical City, Makkah, Saudi Arabia.International journal of environmental research and public health · 2025Article
- Associations of pain phenotypes and pain relief medications with stroke and its subtypes: a prospective cohort study.Scientific reports · 2025Article
- Synergistic effects of chronic pain and diabetes on cardiovascular disease risk: findings from a nationwide cohort study.BMC public health · 2025Article
- Mast cell-derived chymases are essential for the resolution of inflammatory pain in mice.Pain · 2025Article
- A cross-sectional study exploring relationships between triglyceride glucose index, atherogenic index of plasma, and chronic pain: NHANES 1999-2004.Lipids in health and disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Chronic pain affects many people world-wide, and this number is continuously increasing. There is a clear link between chronic pain and the development of cardiovascular disease through activation of the sympathetic nervous system. The purpose of this review is to provide evidence from the literature that highlights the direct relationship between sympathetic nervous system dysfunction and chronic pain. We hypothesize that maladaptive changes within a common neural network regulating the sympathetic nervous system and pain perception contribute to sympathetic overactivation and cardiovascular disease in the setting of chronic pain. We review clinical evidence and highlight the basic neurocircuitry linking the sympathetic and nociceptive networks and the overlap between the neural networks controlling the two.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.