Evidence map›Paper›PMID 36982421›Full record

ArticleInternational journal of molecular sciences2023

Induction of Antimicrobial Protein S100A15 Expression by Oral Microbial Pathogens Is Toll-like Receptors-Dependent Activation of c-Jun-N-Terminal Kinase (JNK), p38, and NF-κB Pathways.

Denis Selimovic, Naji Kharouf, Florence Carrouel, Sofie-Yasmin Hassan, Thomas W Flanagan, Sarah-Lilly Hassan, Mosaad Megahed, Youssef Haikel, Simeon Santourlidis, Mohamed Hassan

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Denis SelimovicInstitut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.
Naji KharoufInstitut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.ORCID 0000-0001-6768-138X
Florence CarrouelHealth, Systemic, Process, UR 4129 Research Unit, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France.ORCID 0000-0002-6823-1636
Sofie-Yasmin HassanDepartment of Chemistry, Faculty of Science, Heinrich-Heine University Duesseldorf, 40225 Duesseldorf, Germany.
Thomas W FlanaganDepartment of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA 70112, USA.
Sarah-Lilly HassanDepartment of Chemistry, Faculty of Science, Heinrich-Heine University Duesseldorf, 40225 Duesseldorf, Germany.
Mosaad MegahedClinic of Dermatology, University Hospital of Aachen, 52074 Aachen, Germany.
Youssef HaikelInstitut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.
Simeon SantourlidisInstitute of Cell Therapeutics and Diagnostics, University Medical Center of Duesseldorf, 40225 Duesseldorf, Germany.ORCID 0000-0002-0743-5336
Mohamed HassanInstitut National de la Santé et de la Recherche Médicale, University of Strasbourg, 67000 Strasbourg, France.ORCID 0000-0002-0336-6425
Heinrich Heine University Düsseldorf · DEInserm · FRDüsseldorf University Hospital · DELouisiana State University Health Sciences Center New Orleans · USTulane University · USUniversitätsklinikum Aachen · DEUniversité Claude Bernard Lyon 1 · FRUniversité de Tours · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antimicrobial protein S100A15 belongs to the S100 family, which is differentially expressed in a variety of normal and pathological tissues. Although the function of S100A15 protein has been discussed in several studies, its induction and regulation in oral mucosa, so far, are largely unknown. In this study, we demonstrate that S100A15 is induced by the stimulation of oral mucosa with gram

Indexed as

Anti-Infective AgentsNF-kappa BHumansJNK Mitogen-Activated Protein KinasesLipopolysaccharidesp38 Mitogen-Activated Protein KinasesS100 Calcium Binding Protein A7Signal TransductionToll-Like Receptor 2Toll-Like Receptor 4Toll-Like ReceptorsAnti-Infective AgentsJNK Mitogen-Activated Protein KinasesLipopolysaccharidesNF-kappa Bp38 Mitogen-Activated Protein KinasesS100A7A protein, humanS100 Calcium Binding Protein A7Toll-Like Receptor 2Toll-Like Receptor 4Toll-Like ReceptorsASK1JNKLPSLTANF-κBp38S100A15TLR2TLR4

Identifiers

PMID36982421
PMCPMC10049289
OpenAlexW4324060668

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read71
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.