Evidence map›Paper›PMID 36982349›Full record

ReviewInternational journal of molecular sciences2023

Kinase Inhibitors in Genetic Diseases.

Lucia D'Antona, Rosario Amato, Carolina Brescia, Valentina Rocca, Emma Colao, Rodolfo Iuliano, Bonnie L Blazer-Yost, Nicola Perrotti

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lucia D'AntonaDepartment of Health Sciences, University "Magna Graecia" at Catanzaro, 88100 Catanzaro, Italy.
Rosario AmatoDepartment of Health Sciences, University "Magna Graecia" at Catanzaro, 88100 Catanzaro, Italy.
Carolina BresciaDepartment of Health Sciences, University "Magna Graecia" at Catanzaro, 88100 Catanzaro, Italy.
Valentina RoccaMedical Genetics Unit, University Hospital "Mater Domini" at Catanzaro, 88100 Catanzaro, Italy.
Emma ColaoMedical Genetics Unit, University Hospital "Mater Domini" at Catanzaro, 88100 Catanzaro, Italy.
Rodolfo IulianoDepartment of Health Sciences, University "Magna Graecia" at Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0002-8524-7402
Bonnie L Blazer-YostDepartment of Biology, Indiana University Purdue University, Indianapolis, IN 46202, USA.ORCID 0000-0002-1899-4555
Nicola PerrottiDepartment of Health Sciences, University "Magna Graecia" at Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0001-8836-5386
Magna Graecia University · ITAzienda Ospedaliero Universitario Mater Domini · ITIndiana University – Purdue University Indianapolis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the years, several studies have shown that kinase-regulated signaling pathways are involved in the development of rare genetic diseases. The study of the mechanisms underlying the onset of these diseases has opened a possible way for the development of targeted therapies using particular kinase inhibitors. Some of these are currently used to treat other diseases, such as cancer. This review aims to describe the possibilities of using kinase inhibitors in genetic pathologies such as tuberous sclerosis, RASopathies, and ciliopathies, describing the various pathways involved and the possible targets already identified or currently under study.

Indexed as

TOR Serine-Threonine KinasesTuberous SclerosisHumansSignal TransductionTOR Serine-Threonine Kinasesgeneticskinase inhibitorsmTOR pathwayRAS pathwayWnt pathway

Identifiers

PMID36982349
PMCPMC10048847
OpenAlexW4323851649

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read32
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.