ReviewInternational journal of molecular sciences2023
Epilepsy and Attention Deficit Hyperactivity Disorder: Connection, Chance, and Challenges.
Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Attention-deficit/hyperactivity disorder in children with epilepsy: A systematic review and meta-analysis of prevalence and risk factors.Epilepsia open · 2024Pooled it
- Pooled it
- Knowledge and awareness of epilepsy management, etiologies, and comorbidities among pediatricians in Palestine.BMC pediatrics · 2026Article
- Epidemiological characteristics of comorbidities in childhood Attention-Deficit/Hyperactivity Disorder and common comorbidity patterns.Frontiers in public health · 2026Article
- Toward the automation of family semantic grids: a pilot exploration of text mining for evidence-informed systemic-relational psychotherapy.Frontiers in child and adolescent psychiatry · 2026Article
- Children and Young Adults Who Used Medication for Attention Deficit Hyperactivity Disorder Faced Increased Cardiac Risks.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- The SASOP/PsychMg child and adolescent attention-deficit/hyperactivity disorder guidelines.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- Novel pharmacological targets for GABAergic dysfunction in ADHD.Neuropharmacology · 2024Review
- Paradigm shift required for translational research on the brain.Experimental & molecular medicine · 2024Review
- Clinical characteristics and impact of comorbidities on the prognosis of senile epilepsy in Southwest China: a retrospective cohort study.Acta epileptologica · 2024Article
- Impact of Vitamin D and IL-1β on Quality of Life in Pediatric Drug-Resistant Epilepsy.Journal of multidisciplinary healthcare · 2024Article
- Assessment of learning abilities and school performance of Sudanese children with epilepsy.Sudanese journal of paediatrics · 2024Article
- Comorbidity of attention deficit hyperactivity disorder in a patient with epilepsy: Staring down the challenge of inattention versus nonconvulsive seizures.Epilepsy & behavior reports · 2024Review
- Hippocampal ΔFosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies.Frontiers in neurology · 2023Article
- Use of cannabidiol in the treatment of drug-refractory epilepsy in children and young adults: A systematic review.Journal of neurosciences in rural practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Comorbidities are common in children with epilepsy, with nearly half of the patients having at least one comorbidity. Attention deficit hyperactivity disorder (ADHD) is a psychiatric disorder characterized by hyperactivity and inattentiveness level disproportional to the child's developmental stage. The burden of ADHD in children with epilepsy is high and can adversely affect the patients' clinical outcomes, psychosocial aspects, and quality of life. Several hypotheses were proposed to explain the high burden of ADHD in childhood epilepsy; the well-established bidirectional connection and shared genetic/non-genetic factors between epilepsy and comorbid ADHD largely rule out the possibility of a chance in this association. Stimulants are effective in children with comorbid ADHD, and the current body of evidence supports their safety within the approved dose. Nonetheless, safety data should be further studied in randomized, double-blinded, placebo-controlled trials. Comorbid ADHD is still under-recognized in clinical practice. Early identification and management of comorbid ADHD are crucial to optimize the prognosis and reduce the risk of adverse long-term neurodevelopmental outcomes. The identification of the shared genetic background of epilepsy and ADHD can open the gate for tailoring treatment options for these patients through precision medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.