Evidence map›Paper›PMID 36982291›Full record

ArticleInternational journal of molecular sciences2023

Secretory Factors from Calcium-Sensing Receptor-Activated SW872 Pre-Adipocytes Induce Cellular Senescence and A Mitochondrial Fragmentation-Mediated Inflammatory Response in HepG2 Cells.

Lautaro Briones-Suarez, Mariana Cifuentes, Roberto Bravo-Sagua

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lautaro Briones-SuarezLaboratory of Obesity and Metabolism (OMEGA), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile.
Mariana CifuentesLaboratory of Obesity and Metabolism (OMEGA), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile.ORCID 0000-0001-9485-3490
Roberto Bravo-SaguaLaboratory of Obesity and Metabolism (OMEGA), Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago 7830490, Chile.ORCID 0000-0001-8873-8699
Advanced Center for Chronic Diseases · CLUniversity of Bío-Bío · CL

Funding

Agencia Nacional de Investigación y Desarrollo FONDAP 15130011Agencia Nacional de Investigación y Desarrollo FONDECYT 11201267Agencia Nacional de Investigación y Desarrollo FONDECYT 1211477Agencia Nacional de Investigación y Desarrollo PAI 77170004-2017University of Bío-Bío C.C. 20503000University of Chile UI-006/19
6 · The paper itself

Abstract

Adipose tissue inflammation in obesity has a deleterious impact on organs such as the liver, ultimately leading to their dysfunction. We have previously shown that activation of the calcium-sensing receptor (CaSR) in pre-adipocytes induces TNF-α and IL-1β expression and secretion; however, it is unknown whether these factors promote hepatocyte alterations, particularly promoting cell senescence and/or mitochondrial dysfunction. We generated conditioned medium (CM) from the pre-adipocyte cell line SW872 treated with either vehicle (CM

Indexed as

Receptors, Calcium-SensingTumor Necrosis Factor-alphaAdipocytesCellular SenescenceHep G2 CellsHumansQuinazolinones3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinoneQuinazolinonesReceptors, Calcium-SensingTumor Necrosis Factor-alphacalcium-sensing receptorcell senescencehepatocytepre-adipocyte

Identifiers

PMID36982291
PMCPMC10049719
OpenAlexW4323664787

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read43
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.