Evidence map›Paper›PMID 36982268›Full record

ArticleInternational journal of molecular sciences2023

Serum Levels of Lipoprotein Lipase Are Increased in Patients with Inflammatory Bowel Disease.

Orvelindo Rodríguez-Hernández, Marta Carrillo-Palau, Alejandro Hernández-Camba, Inmaculada Alonso-Abreu, Laura Ramos, Laura de Armas-Rillo, Candelaria Martín-González, Raquel López-Mejías, Miguel Á González-Gay, Iván Ferraz-Amaro

Open access · goldFull text read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Orvelindo Rodríguez-HernándezDivision of Endocrinology, Hospital Universitario de Canarias, 38320 Tenerife, Spain.
Marta Carrillo-PalauDivision of Gastroenterology, Hospital Universitario de Canarias,38320 Tenerife, Spain.ORCID 0000-0002-1056-8711
Alejandro Hernández-CambaDivision of Gastroenterology, Hospital Universitario de Nuestra Señora de la Candelaria, 38010 Tenerife, Spain.ORCID 0000-0002-8653-207X
Inmaculada Alonso-AbreuDivision of Gastroenterology, Hospital Universitario de Canarias,38320 Tenerife, Spain.ORCID 0000-0003-0406-029X
Laura RamosDivision of Gastroenterology, Hospital Universitario de Canarias,38320 Tenerife, Spain.
Laura de Armas-RilloDivision of Health Sciences, Universidad Europea de Canarias, 38300 Tenerife, Spain.ORCID 0000-0003-1768-2100
Candelaria Martín-GonzálezDivision of Internal Medicine, Hospital Universitario de Canarias, 38320 Tenerife, Spain.ORCID 0000-0002-4702-1840
Raquel López-MejíasEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, 39011 Santander, Spain.ORCID 0000-0003-0548-2689
Miguel Á González-GayDivision of Rheumatology, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.ORCID 0000-0002-7924-7406
Iván Ferraz-AmaroDepartment of Internal Medicine, University of La Laguna (ULL), 38200 Tenerife, Spain.ORCID 0000-0003-0197-5267
Hospital Universitario de Canarias · ESUniversidad de La Laguna · ESHospital Universitario Nuestra Señora de Candelaria · ESInstituto de Investigación Marqués de Valdecilla · ESUniversidad de Cantabria · ESUniversidad Europea de Canarias · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of the lipid profile is commonly found in patients with inflammatory bowel disease (IBD). Lipoprotein lipase (LPL) is a key molecule involved in triglyceride metabolism that plays a significant role in the progression of atherosclerosis. In this study, our aim was to study whether serum LPL levels are different in IBD patients and controls and whether IBD features are related to LPL. This was a cross-sectional study that encompassed 405 individuals; 197 IBD patients with a median disease duration of 12 years and 208 age- and sex-matched controls. LPL levels and a complete lipid profile were assessed in all individuals. A multivariable analysis was performed to determine whether LPL serum levels were altered in IBD and to study their relationship with IBD characteristics. After the fully multivariable analysis, including cardiovascular risk factors and the changes in lipid profile that the disease causes itself, patients with IBD showed significantly higher levels of circulating LPL (beta coefficient 196 (95% confidence interval from 113 to 259) ng/mL,

Indexed as

Colitis, UlcerativeCrohn DiseaseInflammatory Bowel DiseasesCross-Sectional StudiesHumansLipidsLipoprotein LipaseLipidsLipoprotein Lipaseinflammatory bowel diseaselipid profilelipoprotein lipase

Identifiers

PMID36982268
PMCPMC10049227
OpenAlexW4323666921

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read12
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.