Evidence map›Paper›PMID 36982002›Full record

Trial reportInternational journal of environmental research and public health2023

A Cross-Sectional Analysis of the Nicotine Metabolite Ratio and Its Association with Sociodemographic and Smoking Characteristics among People with HIV Who Smoke in South Africa.

Chukwudi Keke, Zane Wilson, Limakatso Lebina, Katlego Motlhaoleng, David Abrams, Ebrahim Variava, Nikhil Gupte, Raymond Niaura, Neil Martinson, Jonathan E Golub and 1 more

Full text readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chukwudi KekeDepartment of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80523, USA.
Zane WilsonDepartment of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80523, USA.
Limakatso LebinaAfrica Health Research Institute, Somkhele, Myeki 3935, South Africa.
Katlego MotlhaolengPerinatal HIV Research Unit, Soweto 1862, South Africa.
David AbramsSchool of Global Public Health, New York University, New York, NY 10003, USA.
Ebrahim VariavaKlerksdorp Tshepong Hospital Complex, Matlosana 2574, South Africa.
Nikhil GupteDepartment of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Raymond NiauraSchool of Global Public Health, New York University, New York, NY 10003, USA.
Neil MartinsonPerinatal HIV Research Unit, Soweto 1862, South Africa.
Jonathan E GolubDepartment of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Jessica L ElfDepartment of Environmental and Radiological Health Science, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-4298-6395

Funding

A Smoking Cessation Trial in HIV-infected patients in South AfricaR01DA030276 · NIDA · JOHNS HOPKINS UNIVERSITY · PI GOLUB, JONATHAN E. · 2011 to 2014
$2.0M
NIDA NIH HHS R01 DA030276NIDA NIH HHS R01DA030276
6 · The paper itself

Abstract

The nicotine metabolite ratio (NMR) is associated with race/ethnicity but has not been evaluated among smokers in the African region. We conducted a cross-sectional analysis of baseline data from a large randomized, controlled trial for smoking cessation among people with HIV (PWH) in South Africa. Urine samples were analyzed for the NMR and evaluated as a binary variable using a cutoff value of the fourth quartile to determine the fastest metabolizers. The median NMR was 0.31 (IQR: 0.31, 0.32; range: 0.29, 0.57); the cut-point for fast metabolizers was ≥0.3174 ng/mL. A high NMR was not associated with the number of cigarettes per day (OR = 1.10, 95% CI: 0.71, 1.70,

Indexed as

HIV InfectionsNicotineCross-Sectional StudiesHumansSmokingSouth AfricaNicotineHIVnicotine metabolite ratioNMRsmokingSouth Africa

Identifiers

PMID36982002
PMCPMC10049339

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.