ArticleInternational journal of environmental research and public health2023
Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination.
Article in International journal of environmental research and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Proactive risk assessment and nursing risk management in chemotherapy drugs: FMECA methodology results.Journal of healthcare risk management : the journal of the American Society for Healthcare Risk Management · 2026Article
- Development and application of a wipe sampling method for detection of antibiotic surface contamination in hospital wards.Annals of work exposures and health · 2026Article
- Buccal micronucleus cytome assay to evaluate cyto-genotoxic effects of occupational exposure to antineoplastic drugs: application on a large sample size of workers furnished by an Italian network of oncological hospitals.Archives of toxicology · 2025Article
- Genotoxicity Induced by Carcinogenic Agents or Occupational Exposure with Sufficient Evidence for Bladder Cancer.Journal of clinical medicine · 2025Review
- Canadian Monitoring Program for Surface Contamination with 11 Antineoplastic Drugs in 126 Centres: Results for 2023.The Canadian journal of hospital pharmacy · 2025Article
- Application of a multifunctional chemotherapy infusion device for reducing antineoplastic drug extravasation.Frontiers in oncology · 2025Article
- Evaluation of the risk of occupational exposure to antineoplastic drugs in healthcare sector: part II - the application of the FMECA method to compare manual vs automated preparation.Arhiv za higijenu rada i toksikologiju · 2024Article
- Evaluation of the risk of occupational exposure to antineoplastic drugs in healthcare sector: part I - medical gloves.Arhiv za higijenu rada i toksikologiju · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antineoplastic drugs used in the treatment of cancers have an intrinsic toxicity, because of their genotoxic, teratogenic, and carcinogenic properties. Their use is recognized as an occupational hazard for healthcare workers (HCWs) who may be exposed. The purpose of this article is to present biological- and environmental-monitoring data collected in twelve French hospitals over eight years. Urine samples were collected from a wide range of HCWs (250 participants) from pharmacy and oncology units, including physicians, pharmacists, pharmacy technicians, nurses, auxiliary nurses, and cleaners. The investigated drugs were cyclophosphamide, ifosfamide, methotrexate, and α-fluoro-β-alanine, the main urinary metabolite of 5-fluorouracil. Wipe samples were collected from various locations in pharmacy and oncology units. More than 50% of participants, from all exposure groups, were contaminated with either drug, depending on the unit, the day, or the task performed. However, workers from oncology units were more frequently exposed than workers from pharmacy units. Significant contamination was detected on various surfaces in pharmacy and oncology units, highlighting potential sources of exposure. Risk-management measures should be implemented to reduce and maintain exposures at lowest-possible levels. In addition, regular exposure assessment, including biological and environmental monitoring, is recommended to ensure the long-term efficiency of the prevention measures.
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