Evidence map›Paper›PMID 36981009›Full record

ArticleGenes2023

Genome-Wide Analysis of Dental Caries Variability Reveals Genotype-by-Environment Interactions.

Tianyu Zou, Betsy Foxman, Daniel W McNeil, Seth M Weinberg, Mary L Marazita, John R Shaffer

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. JBMR plus · 2026
    Article
  3. Article
  4. International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tianyu ZouDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Betsy FoxmanDepartment of Epidemiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-6682-238X
Daniel W McNeilDepartment of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
Seth M WeinbergDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Mary L MarazitaDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-2648-2832
John R ShafferDepartment of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-1897-1131
University of Pittsburgh · USUniversity of Florida · USUniversity of Michigan · US

Funding

Psychosocial Influences on Rural Children's Oral HealthR01DE014899 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOXMAN, BETSY, MARAZITA, MARY L. · 2002 to 2020
$39.9M
LONGITUDINAL STUDY OF FLUORIDE EXPOSURES &FLUORIDER01DE009551 · NIDCR · UNIVERSITY OF IOWA · PI LEVY, STEVEN M. · 1991 to 2008
$4.7M
Dental Caries: Whole Genome Association and Gene x Environment StudiesU01DE018903 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L. · 2007 to 2010
$1.2M
NIDCR NIH HHS R01 DE009551NIDCR NIH HHS R01 DE014899NIDCR NIH HHS U01 DE018903NIH HHS R01-DE014899, 1-U01-DE018903, X01-HG009878, R01-DE09551, and P30-DE10126.
6 · The paper itself

Abstract

Genotype-by-environment interactions (GEI) may influence dental caries, although their effects are difficult to detect. Variance quantitative trait loci (vQTL) may serve as an indicator of underlying GEI effects. The aim of this study was to investigate GEI effects on dental caries by prioritizing variants from genome-wide vQTL analysis. First, we identified vQTLs from ~4.3 M genome-wide variants in three cohorts of white children aged 3-5 (n = 396, n = 328, n = 773) using Levene's test. A total of 39 independent vQTLs with

Indexed as

Dental CariesGene-Environment InteractionChildFemaleGenotypeHumansMaleMonocarboxylic Acid TransportersQuantitative Trait LociMonocarboxylic Acid TransportersSLC5A8 protein, humandental cariesgenome-wide vQTLgenotype-by-environment interactions

Identifiers

PMID36981009
PMCPMC10048401
OpenAlexW4327738700

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read5
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.