ArticleGenes2023
Exploring the Lifetime Effect of Children on Wellbeing Using Two-Sample Mendelian Randomisation.
Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Extending the Use of Mendelian Randomisation With Non-Inherited Variants to Assess Socially Transmitted Parental Exposures Under Assortative Mating.Genetic epidemiology · 2026Article
- Comparison of caffeine consumption behavior with plasma caffeine levels as exposure measures in drug-target mendelian randomization.American journal of epidemiology · 2024Article
- MRSamePopTest: introducing a simple falsification test for the two-sample mendelian randomisation 'same population' assumption.BMC research notes · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundObservational research implies a negative effect of having children on wellbeing.
objectivesTo provide Mendelian randomisation evidence of the effect of having children on parental wellbeing.
designTwo-sample Mendelian randomisation.
settingNon-clinical European ancestry participants.
participantsWe used the UK Biobank (460,654 male and female European ancestry participants) as a source of genotype-exposure associations, the Social Science Genetics Consortia (SSGAC) (298,420 male and female European ancestry participants), and the Within-Family Consortia (effective sample of 22,656 male and female European ancestry participants) as sources of genotype-outcome associations.
interventionsThe lifetime effect of an increase in the genetic liability to having children. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary analysis was an inverse variance weighed analysis of subjective wellbeing measured in the 2016 SSGAC Genome Wide Association Study (GWAS). Secondary outcomes included pleiotropy robust estimators applied in the SSGAC and an analysis using the Within-Family consortia GWAS.
resultsWe did not find strong evidence of a negative (standard deviation) change in wellbeing (β = 0.153 (95% CI: -0.210 to 0.516) per child parented. Secondary outcomes were generally slightly deflated (e.g., -0.049 [95% CI: -0.533 to 0.435] for the Within-Family Consortia and 0.090 [95% CI: -0.167 to 0.347] for weighted median), implying the presence of some residual confounding and pleiotropy.
conclusionsContrary to the existing literature, our results are not compatible with a measurable negative effect of number of children on the average wellbeing of a parent over their life course. However, we were unable to explore non-linearities, interactions, or time-varying effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.