ArticleGenes2023
Deep Learning-Based Feature Extraction with MRI Data in Neuroimaging Genetics for Alzheimer's Disease.
Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Vision transformer autoencoders captures local and non-local features in brain imaging to reveal novel genetic associations.Communications biology · 2026Article
- A review of AI-based radiogenomics in neurodegenerative disease.Frontiers in big data · 2025Review
- Quantum AI for psychiatric diagnosis: enhancing dementia classification with quantum machine learning.Frontiers in psychiatry · 2025Article
- Article
- Deep causal feature extraction and inference with neuroimaging genetic data.Statistics in medicine · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The prognosis and treatment of patients suffering from Alzheimer's disease (AD) have been among the most important and challenging problems over the last few decades. To better understand the mechanism of AD, it is of great interest to identify genetic variants associated with brain atrophy. Commonly, in these analyses, neuroimaging features are extracted based on one of many possible brain atlases with FreeSurf and other popular software; this, however, may cause the loss of important information due to our incomplete knowledge about brain function embedded in these suboptimal atlases. To address the issue, we propose convolutional neural network (CNN) models applied to three-dimensional MRI data for the whole brain or multiple, divided brain regions to perform completely data-driven and automatic feature extraction. These image-derived features are then used as endophenotypes in genome-wide association studies (GWASs) to identify associated genetic variants. When we applied this method to ADNI data, we identified several associated SNPs that have been previously shown to be related to several neurodegenerative/mental disorders, such as AD, depression, and schizophrenia.
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Registered trials
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