Evidence map›Paper›PMID 36980895›Full record

ArticleGenes2023

Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (

Jianzeng Li, Yanchao Ma, Chunxia Cai, Lujie Zhang, Xinxin Liu, Ruirui Jiang, Donghua Li, Zhuanjian Li, Xiangtao Kang, Yadong Tian and 1 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jianzeng LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Yanchao MaCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Chunxia CaiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Lujie ZhangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xinxin LiuCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Ruirui JiangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0002-7863-6186
Donghua LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Zhuanjian LiCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Xiangtao KangCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.ORCID 0000-0002-9628-7135
Yadong TianCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Ruili HanCollege of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China.
Henan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Valgus-valgus deformity (VVD) is a common leg deformity in broilers with inward or outward deviation of the tibiotarsus and tarsometatarsus. The competing endogenous RNA (ceRNA) network plays an essential role in the study of leg disease. However, its role in the etiology and pathogenesis of VVD remains unclear. Here, based on case (VVD) and control (normal) group design, we performed analyses of differentially expressed circRNAs (DEcircRNAs), differentially expressed miRNAs (DEmiRNAs) and differentially expressed mRNAs (DEmRNAs). Transcriptome data derived 86 DEcircRNAs, 13 DEmiRNAs and 410 DEmRNAs. Functional analysis showed that DEmRNAs were significantly enriched in cell cycle, apoptosis, ECM-receptor interaction, FoxO signaling pathway and protein processing synthesis. DEcirc/miRNA-associated DEmRNAs were associated with skeletal and muscle growth and development pathways, including mTOR, Wnt, and VEGF signaling pathways. Subsequently, a circRNA-miRNA-mRNA regulatory network was constructed based on the ceRNA hypothesis, including 8 circRNAs, 6 miRNAs, and 31 mRNAs, which were significantly enriched in the skeletal developmental pathway. Finally, two key mRNAs (

Indexed as

Bird DiseasesGene Regulatory NetworksHindlimbAnimalsBone DiseasesCartilageChickensMaleMicroRNAsRNA, CircularRNA, MessengerMicroRNAsRNA, CircularRNA, Messengerbroilercompeting endogenous RNARNA-seqskeletal developmentvalgus-varus deformity

Identifiers

PMID36980895
PMCPMC10048443
OpenAlexW4322770421

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read27
table measurements read12
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.