ArticleCancers2023
Quantitative Biomarkers Derived from a Novel Contrast-Free Ultrasound High-Definition Microvessel Imaging for Distinguishing Thyroid Nodules.
Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Value of a Predictive Model Based on Multimodal Ultrasound Imaging Biomarkers Combined with Clinical Features in the Diagnosis of Thyroid Nodules.Current medical imaging · 2026Article
- Quantitative Ultrasound Grayscale Analysis and Size of Benign and Malignant Solid Thyroid Nodules.Tomography (Ann Arbor, Mich.) · 2025Article
- Quantitative microvessel orientation biomarkers derived from contrast free ultrasound imaging for cancer diagnosis.Scientific reports · 2025Article
- Deep learning based motion correction in ultrasound microvessel imaging approach improves thyroid nodule classification.Scientific reports · 2025Article
- Article
- Ultrasound-based quantitative microvasculature imaging for early prediction of response to neoadjuvant chemotherapy in patients with breast cancer.Breast cancer research : BCR · 2025Article
- Near-infrared diffuse optical characterization of human thyroid using ultrasound-guided hybrid time-domain and diffuse correlation spectroscopies.Biomedical optics express · 2024Article
- Fast inter-frame motion correction in contrast-free ultrasound quantitative microvasculature imaging using deep learning.Scientific reports · 2024Article
- Article
- Background Noise Removal in Non-Contrast- Enhanced Ultrasound Microvasculature Imaging Using Combined Collaborative, Morphological, and Vesselness Filtering.IEEE access : practical innovations, open solutions · 2024Article
- Article
- Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach.Breast cancer research : BCR · 2023Article
- Preliminary Study on the Value of Contrast-Enhanced Ultrasound in Enhancing Early Vascular Architecture for the Differential Diagnosis of Benign and Malignant Endometrial Lesions.Journal of clinical ultrasound : JCUArticle
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Authors and funding
7 authors.
Funding
Abstract
Low specificity in current ultrasound modalities for thyroid cancer detection necessitates the development of new imaging modalities for optimal characterization of thyroid nodules. Herein, the quantitative biomarkers of a new high-definition microvessel imaging (HDMI) were evaluated for discrimination of benign from malignant thyroid nodules. Without the help of contrast agents, this new ultrasound-based quantitative technique utilizes processing methods including clutter filtering, denoising, vessel enhancement filtering, morphological filtering, and vessel segmentation to resolve tumor microvessels at size scales of a few hundred microns and enables the extraction of vessel morphological features as new tumor biomarkers. We evaluated quantitative HDMI on 92 patients with 92 thyroid nodules identified in ultrasound. A total of 12 biomarkers derived from vessel morphological parameters were associated with pathology results. Using the Wilcoxon rank-sum test, six of the twelve biomarkers were significantly different in distribution between the malignant and benign nodules (all
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