Evidence map›Paper›PMID 36980752›Full record

ArticleCancers2023

Non-Oncogene Addiction of

Magda Spella, Giannoula Ntaliarda, Georgios Skiadas, Anne-Sophie Lamort, Malamati Vreka, Antonia Marazioti, Ioannis Lilis, Eleni Bouloukou, Georgia A Giotopoulou, Mario A A Pepe and 16 more

Registry-linked trialOpen access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06634875 (A Phase IIa, Non-Randomized, Open-Label Dose Expansion Trial of Isunakinra in Combination With Pembrolizumab in Patients With Metastatic or Unresectable, Locally Advanced Colorectal Cancer), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06634875 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Phase IIa, Non-Randomized, Open-Label Dose Expansion Trial of Isunakinra in Combination With Pembrolizumab in Patients With Metastatic or Unresectable, Locally Advanced Colorectal Cancer

TypeinterventionalSponsorBuzzard PharmaceuticalsRan2025 to 2026Enrolled20ConditionsColorectal Cancer MetastaticArmsisunakinra
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Journal of gastrointestinal oncology · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 7 institutions in 3 countries.

Magda SpellaDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.ORCID 0000-0003-2505-7778
Giannoula NtaliardaDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.ORCID 0000-0002-2299-6027
Georgios SkiadasDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.ORCID 0000-0002-7377-8783
Anne-Sophie LamortDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Malamati VrekaDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Antonia MaraziotiDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Ioannis LilisDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Eleni BouloukouDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Georgia A GiotopoulouDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Mario A A PepeDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Stefanie A I WeissComprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany.
Agnese PetreraResearch Unit Protein Science-Core Facility Proteomics, Helmholtz Center Munich-German Research Center for Environmental Health, 80939 Munich, Germany.
Stefanie M HauckResearch Unit Protein Science-Core Facility Proteomics, Helmholtz Center Munich-German Research Center for Environmental Health, 80939 Munich, Germany.ORCID 0000-0002-1630-6827
Ina KochCenter for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich and Asklepios Medical Center, 82131 Gauting, Germany.
Michael LindnerCenter for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich and Asklepios Medical Center, 82131 Gauting, Germany.
Rudolph A HatzCenter for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich and Asklepios Medical Center, 82131 Gauting, Germany.
Juergen BehrDepartment of Internal Medicine V, Ludwig-Maximilian-University of Munich, 81377 Munich, Germany.
Kristina A M ArendtDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.
Ioanna GiopanouDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.ORCID 0000-0003-4393-7517
David BrunnMax Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
Rajkumar SavaiMax Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.ORCID 0000-0003-1538-2091
Dieter E JenneComprehensive Pneumology Center and Institute for Lung Biology and Disease, Helmholtz Center Munich-German Research Center for Environmental Health, 81377 Munich, Germany.
Maarten de ChâteauBuzzard Pharmaceutical, 17165 Stockholm, Sweden.ORCID 0009-0000-2351-0554
Fiona E YullDepartment of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.ORCID 0000-0003-1636-7942
Timothy S BlackwellDepartment of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Georgios T StathopoulosDepartment of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Greece.ORCID 0000-0002-9215-6461
University of Patras · GRHelmholtz Zentrum München · DEAsklepios Fachkliniken München-Gauting · DEVanderbilt University · USGoethe University Frankfurt · DELudwig-Maximilians-Universität München · DEMax Planck Institute for Heart and Lung Research · DE

Funding

MOLECULAR REGULATION OF LUNG INFLAMMATION BY NF-KBR01HL061419 · NHLBI · VANDERBILT UNIVERSITY · PI BLACKWELL, TIMOTHY S · 1999 to 2006
$1.5M
Mechanisms driving airway inflammation in chronic lung diseaseI01BX002378 · VA · VETERANS HEALTH ADMINISTRATION · PI Timothy S. Blackwell · 2014 to 2026
–
BLRD VA I01 BX002378NHLBI NIH HHS R01 HL061419NIH HHS HL61419
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bioluminescencecancerinflammationinterleukin-1βnon-oncogene addictionnuclear factor-κB

Identifiers

PMID36980752
PMCPMC10047096
OpenAlexW4328110701

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read61
identifiers read2
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.