Evidence map›Paper›PMID 36980724›Full record

ArticleCancers2023

MRI Radiomics and Machine Learning for the Prediction of Oncotype Dx Recurrence Score in Invasive Breast Cancer.

Valeria Romeo, Renato Cuocolo, Luca Sanduzzi, Vincenzo Carpentiero, Martina Caruso, Beatrice Lama, Dimitri Garifalos, Arnaldo Stanzione, Simone Maurea, Arturo Brunetti

Open access · goldFull text read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Predictions of Oncotype DXBioengineering (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Article
  7. Application of Machine Learning to Breast MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Valeria RomeoDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-1603-6396
Renato CuocoloDepartment of Medicine, Surgery, and Dentistry, University of Salerno, 84084 Baronissi, Italy.ORCID 0000-0002-1452-1574
Luca SanduzziDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Vincenzo CarpentieroDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0009-0003-5439-0243
Martina CarusoDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-4946-4960
Beatrice LamaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Dimitri GarifalosDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
Arnaldo StanzioneDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-7905-5789
Simone MaureaDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.ORCID 0000-0002-8269-3765
Arturo BrunettiDepartment of Advanced Biomedical Sciences, University of Naples "Federico II", 80131 Naples, Italy.
University of Naples Federico II · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo non-invasively predict Oncotype DX recurrence scores (ODXRS) in patients with MATERIALS AND

methodsPre-operative DCE-MRI of patients with IBC, no history of neoadjuvant therapy prior to MRI, and for which the ODXRS was available, were retrospectively selected from a public dataset. ODXRS was obtained on histological tumor samples and considered as positive if greater than 16 and 26 in patients aged under and over 50 years, respectively. Tumor lesions were manually annotated by three independent operators on DCE-MRI images through 3D ROIs positioning. Radiomic features were therefore extracted and selected using multistep feature selection process. A logistic regression ML classifier was then employed for the prediction of ODXRS.

results248 patients were included, of which 87 with positive ODXRS. 166 (66%) patients were grouped in the training set, while 82 (33%) in the test set. A total of 1288 features was extracted. Of these, 1244 were excluded as 771, 82 and 391 were excluded as not stable (

conclusionsRadiomics and ML applied to pre-operative DCE-MRI in patients with IBC showed promises for the non-invasive prediction of ODXRS, aiding in selecting patients who will benefit from NAC.

Indexed as

breast cancermachine learningmagnetic resonanceneoadjuvant chemotherapyoncotype DXradiomicsrecurrence score

Identifiers

PMID36980724
PMCPMC10047199
OpenAlexW4327968223

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read24
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.