Evidence map›Paper›PMID 36980723›Full record

ReviewCancers2023

Inflammation, Infiltration, and Evasion-Tumor Promotion in the Aging Breast.

Nicole Cruz-Reyes, Derek C Radisky

Open access · goldFull text readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicole Cruz-ReyesDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7511-6169
Derek C RadiskyDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
Mayo Clinic in Florida · US

Funding

Biomarkers to Improve Targeting of Breast Cancer Prevention in Women with Atypical HyperplasiaR01CA237607 · NCI · MAYO CLINIC ROCHESTER · PI DEGNIM, AMY C, RADISKY, DEREK C · 2020 to 2024
$4.2M
Targeted Prevention of Postpartum-Related Breast Cancer (PRBC)R01CA262393 · NCI · MAYO CLINIC JACKSONVILLE · PI Derek C Radisky, Kathryn Jean Ruddy · 2022 to 2026
$3.0M
Involution-based biomarkers of breast cancer riskR01CA237602 · NCI · MAYO CLINIC JACKSONVILLE · PI DEGNIM, AMY C, RADISKY, DEREK C · 2020 to 2024
$2.8M
NCI NIH HHS CA237602NCI NIH HHS R01 CA237602NCI NIH HHS R01 CA237607NCI NIH HHS R01 CA262393
6 · The paper itself

Abstract

Breast cancer is a significant cause of morbidity and mortality in women, with over two million new cases reported worldwide each year, the majority of which occur in post-menopausal women. Despite advances in early detection and treatment, approximately one-third of patients diagnosed with breast cancer will develop metastatic disease. The pathogenesis and progression of breast cancer are influenced by a variety of biological and social risk factors, including age, ethnicity, pregnancy status, diet, and genomic alterations. Recent advancements in breast cancer research have focused on harnessing the power of the patient's adaptive and innate immune systems for diagnostic and therapeutic purposes. The breast immune microenvironment plays a critical role in regulating tissue homeostasis and resistance to tumorigenesis. In this review, we explore the dynamic changes in the breast immune microenvironment that occur with age, how these changes impact breast cancer development and progression, and how targeted therapeutic interventions that leverage the immune system can be used to improve patient outcomes. Our review emphasizes the importance of understanding the complex interplay between aging, the immune system, and breast cancer, and highlights the potential of immune-based therapies in the fight against this devastating disease.

Indexed as

agingbreast cancerimmune systemimmunoediting

Identifiers

PMID36980723
PMCPMC10046531
OpenAlexW4327968448

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read3
identifiers read6
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.