Evidence map›Paper›PMID 36980634›Full record

ReviewCancers2023

Non-Surgical Locoregional Therapies Alone or in Combination with Systemic Therapy in Patients with Hepatocellular Carcinoma.

Perla Chami, William Jarnagin, Ghassan K Abou-Alfa, James Harding, Neal Kim, Haibo Lin, Maria El Homsi, Christopher Crane, Carla Hajj

Open access · goldFull text readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Non-Thermal Liver Ablation: Existing and New Technology.Seminars in interventional radiology · 2023
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Perla ChamiDepartment of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut 1107, Lebanon.
William JarnaginMemorial Sloan Kettering Cancer Center, New York, NY 10027, USA.
Ghassan K Abou-AlfaMemorial Sloan Kettering Cancer Center, New York, NY 10027, USA.
James HardingMemorial Sloan Kettering Cancer Center, New York, NY 10027, USA.
Neal KimMemorial Sloan Kettering Cancer Center, New York, NY 10027, USA.
Haibo LinNew York Proton Center, New York, NY 10035, USA.
Maria El HomsiMemorial Sloan Kettering Cancer Center, New York, NY 10027, USA.ORCID 0000-0002-8483-3653
Christopher CraneMemorial Sloan Kettering Cancer Center, New York, NY 10027, USA.
Carla HajjMemorial Sloan Kettering Cancer Center, New York, NY 10027, USA.
Memorial Sloan Kettering Cancer Center · USAmerican University of Beirut · LBNew York Proton Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver cancer, representing the third-leading cause of cancer-related deaths worldwide. Curative intent treatment options for patients with HCC include liver transplantation, resection and ablation of small lesions. Other potentially curative therapies include cryoablation, microwave ablation and percutaneous alcohol injection. For locally advanced disease, different arterially directed therapies including transarterial chemoembolization and selective internal radiation therapy, plus external beam radiation including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, stereotactic body radiation therapy and proton beam therapy, are available or studied. Systemic therapies based on checkpoint inhibitors and tyrosine kinase inhibitors are available for the management of metastatic HCC and sometimes for locally advanced disease. Combinations of locoregional therapies with systemic drugs are currently the subject of several clinical trials.

Indexed as

ablationablative radiation therapychemoembolizationcombination therapyhepatocellular carcinomainterventional radiologyproton beam therapyradioembolizationstereotactic body radiation therapy

Identifiers

PMID36980634
PMCPMC10046599
OpenAlexW4324144230

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read70
identifiers read33
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.