Evidence map›Paper›PMID 36980550›Full record

ReviewCancers2023

Mast Cell Leukemia: An Update with a Practical Review.

Magda Zanelli, Martina Quintini, Salvatore Magnasco, Lara Aprile, Andrea Palicelli, Maurizio Zizzo, Francesca Sanguedolce, Stefano Ricci, Saverio Pancetti, Valeria Zuccalà and 8 more

Full text readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Mastocytosis.Nature reviews. Disease primers · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Magda ZanelliPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.ORCID 0000-0002-8733-9933
Martina QuintiniHematology, Centro di Ricerca Emato-Oncologica-C.R.E.O., University of Perugia, 06129 Perugia, Italy.
Salvatore MagnascoPathology Unit, Ospedale SS Annunziata di Taranto, 74121 Taranto, Italy.
Lara AprileHematology Unit, Presidio Ospedaliero S.G. Moscati di Taranto, 74010 Taranto, Italy.
Andrea PalicelliPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.ORCID 0000-0003-2299-5160
Maurizio ZizzoSurgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.ORCID 0000-0001-9841-7856
Francesca SanguedolcePathology Unit, Policlinico Riuniti, University of Foggia, 71122 Foggia, Italy.
Stefano RicciPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.ORCID 0000-0002-4289-954X
Saverio PancettiPathology Unit, Humanitas University, Pieve Emanuele, 20072 Milano, Italy.
Valeria ZuccalàPathology Unit, Pugliese-Ciaccio Hospital Catanzaro, 88100 Catanzaro, Italy.
Veronica MartinoPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Giuseppe BroggiDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" Anatomic Pathology, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2576-6523
Rosario CaltabianoDepartment of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia" Anatomic Pathology, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-8591-8010
Alberto CavazzaPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Paola ParentePathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy.ORCID 0000-0003-0591-6723
Cristina MecucciHematology, Centro di Ricerca Emato-Oncologica-C.R.E.O., University of Perugia, 06129 Perugia, Italy.
Giovanni MartinoHematology, Centro di Ricerca Emato-Oncologica-C.R.E.O., University of Perugia, 06129 Perugia, Italy.
Stefano AscaniPathology Unit, Azienda Ospedaliera Santa Maria di Terni, University of Perugia, 05100 Terni, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cell leukemia (MCL) is the leukemic form of SM with at least 20% mostly immature mast cells on bone marrow aspirate. MCL may develop de novo, in the absence of a prior SM, or it may represent a progression from a previous SM. MCL may be sub-divided into the more frequent, aggressive acute form with signs of organ damage (C-findings) and the chronic form lacking C-findings and presenting a more stable course, although over time, progression to acute MCL is common. The 2022 WHO subtype of MCL with an associated hematological neoplasm was renamed MCL with an associated myeloid neoplasm in the 2022 International Consensus Classification (ICC). The relevance of the distinction between the leukemic and aleukemic forms based on the percentage of circulating mast cells is a matter of debate. The current knowledge on MCL is restricted mainly to single reports or case series with a limited number of larger studies. Our aim is to provide a comprehensive overview of this rare disease in terms of clinical manifestations, morphology, phenotype, molecular characteristics, differential diagnosis, outcome and treatment. A general overview on mastocytosis is also included.

Indexed as

KIT mutationmast cell leukemiaMCL-AHNMCL-AMNmidostaurinsystemic mastocytosis

Identifiers

PMID36980550
PMCPMC10046872

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read84
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.