Evidence map›Paper›PMID 36980531›Full record

ArticleCancers2023

Tumor-Stroma Ratio in Basaloid and Conventional Laryngeal Squamous Cell Carcinoma: Prognostic Significance and Concordance in Paired Biopsies and Surgical Samples.

Gino Marioni, Stefano Taboni, Marta Sbaraglia, Leonardo Franz, Tommaso Saccardo, Anna Colombo, Camilla Zimello, Anna Chiara Frigo, Marco Ferrari, Lara Alessandrini

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In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gino MarioniOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy.ORCID 0000-0001-8751-0588
Stefano TaboniOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy.
Marta SbaragliaPathological Anatomy Unit, Department of Medicine DIMED, University of Padova, 35100 Padova, Italy.
Leonardo FranzOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy.ORCID 0000-0002-2306-4088
Tommaso SaccardoOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy.
Anna ColomboOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy.
Camilla ZimelloOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy.
Anna Chiara FrigoDepartment of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, 35100 Padova, Italy.ORCID 0000-0001-9705-4459
Marco FerrariOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy.ORCID 0000-0002-4023-0121
Lara AlessandriniPathological Anatomy Unit, Department of Medicine DIMED, University of Padova, 35100 Padova, Italy.

Funding

University of Padua DOR2215418/22
6 · The paper itself

Abstract

Basaloid squamous cell carcinoma (BSCC) is a subtype of squamous cell carcinoma (SCC) associated with a poor prognosis. Tumor-stroma ratio (TSR) has been introduced as a prognostic feature in many solid tumors. TSR was investigated in a series of laryngeal BSCCs and compared with a group of stage-matched conventional SCCs (cSCCs), in both preoperative and surgical specimens, with the intent of ascertaining the more aggressive behavior of BSCC and verifying the presence of stromal-related causes. A series of 14 consecutive laryngeal BSCCs and a control group of 28 stage-matched conventional cSCCs were analyzed. A higher nodal metastasis presence was found in BSCCs (57.1% vs. 28.6%). The recurrence rate was 33.5% and 63.6% in the cSCC and BSCC groups; disease-free survival (DFS) was higher, though not significantly, in patients with cSCC. TSR, large cell nests, and tumor budding showed a moderate to very good agreement, and stroma type a good to very good agreement between biopsies and surgical specimens in the cSCC group. In the BSCC group, agreement was poor to very good for TSR and stroma type, and good to very good for large cell nests and tumor budding. Age was the only feature significant in predicting recurrence in the BSCC group (

Indexed as

basaloid squamous cell carcinomabiopsiesconcordancelarynxprognosissurgical specimenstumor-stroma ratio

Identifiers

PMID36980531
PMCPMC10046013

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