Evidence map›Paper›PMID 36980529›Full record

ReviewCancers2023

Biological Role and Clinical Implications of

Daniela Di Carlo, Julia Chisholm, Anna Kelsey, Rita Alaggio, Gianni Bisogno, Veronique Minard-Colin, Meriel Jenney, Raquel Dávila Fajardo, Johannes H M Merks, Janet M Shipley and 1 more

Registry-linked trialOpen access · goldFull text readReview
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04625907 (FaR-RMS), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04625907 phase1 / phase2recruitingnot on this map

FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcoma

TypeinterventionalSponsorUniversity of BirminghamRan2020 to 2030Enrolled1,672ConditionsRhabdomyosarcomaArmsIrinotecan, Actinomycin D, Doxorubicin, Ifosfamide, Vincristine
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Orthopaedic Implant-Associated Rhabdomyosarcoma.The Journal of the American Academy of Orthopaedic Surgeons · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 4 countries.

Daniela Di CarloDepartment of Women's and Children's Health, University of Padova, 35128 Padua, Italy.
Julia ChisholmChildren and Young People's Unit, Royal Marsden Hospital, Institute of Cancer Research, Sutton SM2 5NG, UK.ORCID 0000-0003-3479-7997
Anna KelseyDepartment of Pediatric Histopathology, Manchester University Foundation Trust, Manchester M13 9WL, UK.
Rita AlaggioPathology Unit, Department of Laboratories, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Gianni BisognoDepartment of Women's and Children's Health, University of Padova, 35128 Padua, Italy.ORCID 0000-0003-4462-5523
Veronique Minard-ColinDepartment of Pediatric and Adolescent Oncology, INSERM U1015, Gustave Roussy, Université Paris-Saclay, 94800 Villejuif, France.
Meriel JenneyDepartment of Pediatric Oncology, Children's Hospital for Wales, Cardiff CF14 4XW, UK.
Raquel Dávila FajardoDepartment of Radiation Oncology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.ORCID 0000-0002-4729-825X
Johannes H M MerksPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0001-7659-1028
Janet M ShipleySarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.
Joanna L SelfeSarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.
Institute of Cancer Research · GBUniversity of Padua · ITBambino Gesù Children's Hospital · ITInserm · FRManchester University NHS Foundation Trust · GBNoah's Ark Children's Hospital for Wales · GBUniversity Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major progress in recent decades has furthered our clinical and biological understanding of rhabdomyosarcoma (RMS) with improved stratification for treatment based on risk factors. Clinical risk factors alone were used to stratify patients for treatment in the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) RMS 2005 protocol. The current EpSSG overarching study for children and adults with frontline and relapsed rhabdomyosarcoma (FaR-RMS NCT04625907) includes

Indexed as

childrenhigh-riskMYOD1sclerosing rhabdomyosarcomaspindle cell

Identifiers

PMID36980529
PMCPMC10046495
OpenAlexW4323566206

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read46
identifiers read1
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.