Evidence map›Paper›PMID 36980502›Full record

ArticleDiagnostics (Basel, Switzerland)2023

SARS-CoV-2 Neutralizing Antibodies in Mexican Population: A Five Vaccine Comparison.

Fernando Alcorta-Nuñez, Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores, Miguel Ángel Garza, Moisés González-Escamilla, Patricia Rodríguez-Niño, Juan Francisco González-Guerrero, Adelina Alcorta-Garza, Oscar Vidal-Gutiérrez, Genaro A Ramírez-Correa and 1 more

Full text read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fernando Alcorta-NuñezServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.ORCID 0000-0003-3309-6144
Diana Cristina Pérez-IbaveServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.
Carlos Horacio Burciaga-FloresServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.ORCID 0000-0002-7723-8354
Miguel Ángel GarzaDepartment of Molecular Science, U.T. Health Rio Grande Valley, McAllen, TX 78503, USA.
Moisés González-EscamillaServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.
Patricia Rodríguez-NiñoServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.
Juan Francisco González-GuerreroServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.
Adelina Alcorta-GarzaServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.
Oscar Vidal-GutiérrezServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.
Genaro A Ramírez-CorreaDepartment of Molecular Science, U.T. Health Rio Grande Valley, McAllen, TX 78503, USA.
María Lourdes Garza-RodríguezServicio de Oncología, Centro Universitario Contra el Cáncer (CUCC), Hospital Universitario "Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey 64460, Nuevo León, Mexico.ORCID 0000-0001-7096-2713

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutralizing antibodies (NAs) are key immunological markers and are part of the humoral response of the adaptive immune system. NA assays determine the presence of functional antibodies to prevent SARS-CoV-2 infection. We performed a real-world evidence study to detect NAs that confer protection against SARS-CoV-2 after the application of five vaccines (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, and CanSino) in the Mexican population. Side effects of COVID-19 vaccines and clinical and demographic factors associated with low immunogenicity were also evaluated. A total of 242 SARS-CoV-2-vaccinated subjects were recruited. Pfizer/BioNTech and Moderna proved the highest percentage of inhibition in a mono-vaccine scheme. Muscular pain, headache, and fatigue were the most common adverse events. None of the patients reported severe adverse events. We found an estimated contagion-free time of 207 (IQR: 182-231) and 187 (IQR: 184-189) days for Pfizer/BioNTech and CanSino in 12 cases in each group. On the basis of our results, we consider that the emerging vaccination strategy in Mexico is effective and safe.

Indexed as

COVID-19COVID-19 vaccinesELISAneutralizing antibodiesSARS-CoV-2vaccination

Identifiers

PMID36980502
PMCPMC10046906

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read51
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.