Evidence map›Paper›PMID 36980244›Full record

ArticleCells2023

ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition.

Lina Sui, Qian Du, Anthony Romer, Qi Su, Pauline L Chabosseau, Yurong Xin, Jinrang Kim, Sandra Kleiner, Guy A Rutter, Dieter Egli

Open access · goldFull text read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. A loss of function variant inmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Multiple genetic variants at the SLC30A8 locus affect local super-enhancer activity and influence pancreatic β-cell survival and function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  7. Multiple genetic variants at thebioRxiv : the preprint server for biology · 2023
    Article
  8. Impact of anFrontiers in endocrinology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Lina SuiDepartments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA.
Qian DuDepartments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA.
Anthony RomerDepartments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-3550-1601
Qi SuRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Pauline L ChabosseauCR-CHUM, Faculté de Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Yurong XinRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Jinrang KimRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Sandra KleinerRegeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Guy A RutterCR-CHUM, Faculté de Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada.ORCID 0000-0001-6360-0343
Dieter EgliDepartments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA.
Columbia University · USRegeneron (United States) · USNanyang Technological University · SGUniversité de Montréal · CA

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
Phase II Trial of HOKT3gamma 1 (ALA-ALA) in Type 1 DiabetesR01DK057846 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold · 2000 to 2026
$11.1M
Mice with autologous human T1D-derived immune systems and iPSC-derived beta cellsUC4DK104207 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2014 to 2014
$3.8M
Medical Research Council MR/R022259/1NIDDK NIH HHS P30 DK026687NIDDK NIH HHS R01 DK057846NIDDK NIH HHS UC4 DK104207Wellcome TrustWellcome Trust WT212625/Z/18/Z
6 · The paper itself

Abstract

The rare

Indexed as

Cation Transport ProteinsDiabetes Mellitus, Type 2Human Embryonic Stem CellsZincZinc Transporter 8AnimalsApoptosisHumansInsulinLoss of Function MutationMiceMutationCation Transport ProteinsInsulinZincZinc Transporter 8diabetesSLC30A8stem cellstem cell biologytype 2 diabeteszinc

Identifiers

PMID36980244
PMCPMC10047077
OpenAlexW4324360807

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read89
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.