Evidence map›Paper›PMID 36980192›Full record

ArticleCells2023

Expression of Checkpoint Molecules in the Tumor Microenvironment of Intrahepatic Cholangiocarcinoma: Implications for Immune Checkpoint Blockade Therapy.

Lara Heij, Jan Bednarsch, Xiuxiang Tan, Mika Rosin, Simone Appinger, Konrad Reichel, Dana Pecina, Michail Doukas, Ronald M van Dam, Juan Garcia Vallejo and 6 more

Open access · goldFull text read
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Advances in Immunotherapy for Intrahepatic Cholangiocarcinoma.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 4 countries.

Lara HeijDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-0602-3356
Jan BednarschDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0001-8143-6452
Xiuxiang TanDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Mika RosinDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Simone AppingerDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Konrad ReichelDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Dana PecinaDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Michail DoukasDepartment of Pathology, Erasmus Medical Center Rotterdam, 3000 CB Rotterdam, The Netherlands.ORCID 0000-0002-8611-840X
Ronald M van DamDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Juan Garcia VallejoDepartment of Molecular Cell Biology & Immunology, VU University Medical Center, 1081 HZ Amsterdam, The Netherlands.
Florian UlmerDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Sven LangDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, 40225 Duesseldorf, Germany.
Flavio G RochaDivision of Surgical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.
Shivan SivakumarDepartment of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
Ulf Peter NeumannDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.
RWTH Aachen University · DEMaastricht University · NLUniversity Medical Center · USAmsterdam UMC Location Vrije Universiteit Amsterdam · NLDüsseldorf University Hospital · DEOregon Health & Science University · USUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

B7-H1 AntigenCholangiocarcinomaHepatitis A Virus Cellular Receptor 2HumansImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorReceptors, ImmunologicTumor MicroenvironmentB7-H1 AntigenHepatitis A Virus Cellular Receptor 2Immune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorReceptors, Immunologiccheckpoint moleculescholangiocarcinomaimmunotherapymultiplexed imagingtumor microenvironment

Identifiers

PMID36980192
PMCPMC10047585
OpenAlexW4323847897

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read9
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.