Evidence map›Paper›PMID 36980071›Full record

ArticleChildren (Basel, Switzerland)2023

Gut Leakage Markers and Cognitive Functions in Patients with Attention-Deficit/Hyperactivity Disorder.

Sheng-Yu Lee, Sung-Chou Li, Chia-Yu Yang, Ho-Chang Kuo, Wen-Jiun Chou, Liang-Jen Wang

Registry-linked trialOpen access · goldFull text read
In one paragraph

Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07756255 (Feasibility, Safety and Tolerability of Fecal Microbiota Transplantation in an Adolescent Population With Attention Deficit Hyperactivity Disorder), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07756255 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Feasibility, Safety and Tolerability of Fecal Microbiota Transplantation in an Adolescent Population With Attention Deficit Hyperactivity Disorder (ADHD)

TypeinterventionalSponsorUniversity of CalgaryRan2026 to 2029Enrolled64ConditionsADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined TypeArmsFecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID, Placebo Vancomycin, Placebo Nitazoxanide
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The Relation of Zonulin and Intestinal Fatty Acid-binding Protein with Cognitive Functions in Patients with Bipolar Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Article
  3. Nutrients · 2026
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sheng-Yu LeeDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.ORCID 0000-0001-7796-9643
Sung-Chou LiDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.ORCID 0000-0002-3016-9718
Chia-Yu YangDepartment of Microbiology and Immunology/Molecular Medicine Research Center, Chang Gung University, Taoyuan 333, Taiwan.
Ho-Chang KuoDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0002-3295-2984
Wen-Jiun ChouDepartment of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Liang-Jen WangDepartment of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.ORCID 0000-0002-5320-1151
Chang Gung University · TWKaohsiung Medical University · TWKaohsiung Veterans General Hospital · TW

Funding

Kaohsiung Chang Gung Memorial Hospital CMRPG8E1441 and CMRPG8K0761
6 · The paper itself

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a commonly seen mental disorder in children. Intestinal permeability may be associated with the pathogenesis of ADHD. The study herein investigated the role of gut leakage biomarkers in the susceptibility of ADHD. A total of 130 children with ADHD and 73 healthy controls (HC) individuals were recruited. Serum concentrations of zonulin, occludin, and defensin (DEFA1) were determined. Visual attention was assessed with Conners' continuous performance test (CPT). In order to rate participants' ADHD core symptoms at home and school, their parents and teachers completed the Swanson, Nolan, and Pelham-Version IV Scale (SNAP-IV), respectively. We found significantly lower DEFA1 levels in the ADHD group compared to that in the HC group (

Indexed as

ADHDbiomarkerscognitive functiongut leakageneurodevelopment

Identifiers

PMID36980071
PMCPMC10047799
OpenAlexW4323318754

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read5
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.