ArticleBiomedicines2023
Acute Kidney Injury Associated with Severe SARS-CoV-2 Infection: Risk Factors for Morbidity and Mortality and a Potential Benefit of Combined Therapy with Tocilizumab and Corticosteroids.
Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- COVID-19 and diabetic ketoacidosis: National outcomes, predictors, and resource utilization in the United States.Journal of diabetes investigation · 2026Article
- Early Changes in Renal Function as Predictors of In-Hospital Mortality in COVID-19 Patients.Life (Basel, Switzerland) · 2026Article
- Unsupervised Machine Learning in Identification of Septic Shock Phenotypes and Their In-Hospital Outcomes: A Multicenter Cohort Study.Journal of clinical medicine · 2025Article
- Effects of tocilizumab on renal function and oxidative stress in an experimental model of acute ischemic kidney injury.Revista da Escola de Enfermagem da U S P · 2025Article
- Emerging Trends in Complications Associated with SARS-CoV-2 Infection.Biomedicines · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is a common complication in patients with severe COVID-19.
methodsWe retrospectively reviewed 249 patients admitted to an intensive care unit (ICU) during the first wave of the pandemic to determine risk factors for AKI. Demographics, comorbidities, and clinical and outcome variables were obtained from electronic medical records.
resultsUnivariate analysis revealed older age, higher admission serum creatinine, elevated Sequential Organ Failure Assessment (SOFA) score, elevated admission D-Dimer, elevated CRP on day 2, mechanical ventilation, vasopressor requirement, and azithromycin usage as significant risk factors for AKI. Multivariate analysis demonstrated that higher admission creatinine (
conclusionThis study confirms the high rate of AKI and associated mortality among COVID-19 patients admitted to ICUs and suggests a role for inflammation and/or coagulopathy in AKI development. One should consider the possibility that early administration of anti-inflammatory agents, as is now routinely conducted in the management of COVID-19-associated acute respiratory distress syndrome, may improve clinical outcomes in patients with AKI.
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Registered trials
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