Evidence map›Paper›PMID 36979812›Full record

ArticleBiomedicines2023

PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in

Kyong-Hwa Kang, Ji Eun Han, Hyunjin Kim, Sohee Kim, Young Bin Hong, Jeanho Yun, Soo Hyun Nam, Byung-Ok Choi, Hyongjong Koh

Open access · goldFull text read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kyong-Hwa KangDepartment of Pharmacology, Dong-A University College of Medicine, Busan 49201, Republic of Korea.
Ji Eun HanDepartment of Pharmacology, Dong-A University College of Medicine, Busan 49201, Republic of Korea.
Hyunjin KimDepartment of Pharmacology, Dong-A University College of Medicine, Busan 49201, Republic of Korea.
Sohee KimDepartment of Pharmacology, Dong-A University College of Medicine, Busan 49201, Republic of Korea.
Young Bin HongNeuroscience Translational Research Solution Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea.
Jeanho YunNeuroscience Translational Research Solution Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea.ORCID 0000-0001-7700-5123
Soo Hyun NamPeripheral Neuropathy Research Center, Dong-A University College of Medicine, Busan 49201, Republic of Korea.
Byung-Ok ChoiDepartment of Neurology, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.
Hyongjong KohDepartment of Pharmacology, Dong-A University College of Medicine, Busan 49201, Republic of Korea.ORCID 0000-0003-2594-4799
Dong-A University · KRSungkyunkwan University · KR

Funding

Korea Basic Science Institute 2021R1A6C101A425National Research Foundation of Korea 2016R1A5A2007009National Research Foundation of Korea 2020R1F1A105165912
6 · The paper itself

Abstract

Charcot-Marie-Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait. Missense mutations in the gene encoding the small heat shock protein HSPB8 (HSP22) have been associated with hereditary neuropathies, including CMT. HSPB8 is a member of the small heat shock protein family sharing a highly conserved α-crystallin domain that is critical to its chaperone activity. In this study, we modeled

Indexed as

Charcot–Marie–Tooth diseaseDrosophilaHSPB8parkinperipheral neuropathyPINK1

Identifiers

PMID36979812
PMCPMC10045361
OpenAlexW4323841758

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read18
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.