ReviewBiomedicines2023
Polypropylene Pelvic Mesh: What Went Wrong and What Will Be of the Future?
Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- A Systematic Review of Graft-Related Complications and Recurrence Following Minimally Invasive Sacrocolpopexy With Xenografts and Allografts.BJOG : an international journal of obstetrics and gynaecology · 2026Pooled it
- Oriented hydrogel biomimicking muscle fibers to treat pelvic organ prolapse via integrated immunomodulation and electrical stimulation.Materials today. Bio · 2026Article
- Magnetic resonance imaging for visualization, segmentation and 3D reconstruction of surgical meshes in the lower abdomen: a systematic review.Abdominal radiology (New York) · 2026Review
- Antimicrobial Coating of Surgical Meshes by Laser-Induced Nanocarbon Synthesis and Transfer.ACS applied polymer materials · 2026Article
- Bony pelvic resection is a risk factor for pelvic abscess after total pelvic exenteration for pelvic malignancies.Surgery today · 2026Article
- Proteomic insights into vaginal mesh complications and treatment targets.Acta biomaterialia · 2025Article
- From Mesh to Modern Therapies: An Updated Narrative Review on Urogenital Prolapse.Journal of clinical medicine · 2025Review
- Significance of Textile Properties for the Design of a New Pelvic Implant to Treat Pelvic Organ Prolapse.International urogynecology journal · 2025Review
- Biodegradable Polyesters: Approaches to Increase Degradation Rates for Biomedical Applications.ACS macro letters · 2025Review
- Retrospective comparative study on efficacy and safety of different surgical procedures for pelvic organ prolapse.Scientific reports · 2025Article
- Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering.Gels (Basel, Switzerland) · 2025Review
- Predicting Transvaginal Surgical Mesh Exposure Outcomes Using an Integrated Dataset of Blood Cytokine Levels and Medical Record Data: Machine Learning Approach.JMIR formative research · 2025Article
- Platelet-Rich Plasma and Fractional COInternational urogynecology journal · 2025Article
- New Rat Model Mimicking Sacrocolpopexy for POP Treatment and Biomaterials Testing via Unilateral Presacral Suspension.International urogynecology journal · 2025Article
- BioHastalex modified with silver nanolayers and heat treatment for antibacterial properties.Heliyon · 2025Article
- Article
- A Novel Graphene-Based Nanomaterial for the Development of a Pelvic Implant to Treat Pelvic Organ Prolapse.Journal of functional biomaterials · 2024Article
- Anterior Colporrhaphy and Paravaginal Repair for Anterior Compartment Prolapse: A Review.Medicina (Kaunas, Lithuania) · 2024Review
- Surface activation of Hastalex by vacuum argon plasma for cytocompatibility enhancement.Heliyon · 2024Article
- Acellular Dermal Matrices as an New Alternative for Treatment in Reproductive Organ Static Disorders: A Pilot Study.Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolypropylene (PP) pelvic mesh is a synthetic mesh made of PP polymer used to treat pelvic organ prolapse (POP). Its use has become highly controversial due to reports of serious complications. This research critically reviews the current management options for POP and PP mesh as a viable clinical application for the treatment of POP. The safety and suitability of PP material were rigorously studied and critically evaluated, with consideration to the mechanical and chemical properties of PP. We proposed the ideal properties of the 'perfect' synthetic pelvic mesh with emerging advanced materials.
methodsWe performed a literature review using PubMed/Medline, Embase, Cochrane Library (Wiley) databases, and ClinicalTrials.gov databases, including the relevant keywords: pelvic organ prolapse (POP), polypropylene mesh, synthetic mesh, and mesh complications.
resultsThe results of this review found that although PP is nontoxic, its physical properties demonstrate a significant mismatch between its viscoelastic properties compared to the surrounding tissue, which is a likely cause of complications. In addition, a lack of integration of PP mesh into surrounding tissue over longer periods of follow up is another risk factor for irreversible complications.
conclusionsPP mesh has caused a rise in reports of complications involving chronic pain and mesh exposure. This is due to the mechanical and physicochemical properties of PP mesh. As a result, PP mesh for the treatment of POP has been banned in multiple countries, currently with no alternative available. We propose the development of a pelvic mesh using advanced materials including emerging graphene-based nanocomposite materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.