Evidence map›Paper›PMID 36979702›Full record

ArticleBiomedicines2023

Michael Adduct of Sulfonamide Chalcone Targets Folate Metabolism in Brugia Malayi Parasite.

Priyanka S Bhoj, Sandeep P Bahekar, Shambhavi Chowdhary, Namdev S Togre, Nitin P Amdare, Lingaraj Jena, Kalyan Goswami, Hemant Chandak

Open access · goldFull text read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Priyanka S BhojDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 411002, India.ORCID 0000-0002-8254-0021
Sandeep P BahekarDepartment of Chemistry, G. S. Science, Arts and Commerce College, Sant Gadge Baba Amravati University, Khamgaon 444303, India.
Shambhavi ChowdharyDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 411002, India.
Namdev S TogreDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 411002, India.ORCID 0000-0001-5840-6458
Nitin P AmdareDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 411002, India.ORCID 0000-0001-9030-630X
Lingaraj JenaDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 411002, India.
Kalyan GoswamiDepartment of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 411002, India.
Hemant ChandakDepartment of Chemistry, G. S. Science, Arts and Commerce College, Sant Gadge Baba Amravati University, Khamgaon 444303, India.ORCID 0000-0003-2052-9035
Mahatma Gandhi Institute of Medical Sciences · INSant Gadge Baba Amravati University · IN

Funding

Department of Biotechnology Id.BT/PR/4988/INF/22/155/2012Department of Science and Technology SR/FST/LSI-470/2010University Grants Commission F. No. 41-335 / 2012 (SR) dt.13.07.2012
6 · The paper itself

Abstract

A series of Michael adducts of malononitrile and sulfonamide chalcones were synthesized, characterized, and evaluated for their antifilarial activity. Out of 14 compounds, N-(4-(4,4-dicyano-3-p-tolylbutanoyl)phenyl)benzenesulfonamide showed favorable drug-likeness properties with marked antifilarial effects at micro-molar dosages. Apoptosis in

Indexed as

antifilarialdihydrofolate reductasefolate metabolismMichael adductssulfonamide chalcone

Identifiers

PMID36979702
PMCPMC10045823
OpenAlexW4322628466

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read156
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.