ReviewBiomedicines2023
Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction.
Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.
- Adiponectin and Polycystic Ovary Syndrome in Adolescent Girls: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Trial
- Endocrinological aspects of sarcopenic obesity.Annals of medicine · 2026Review
- Serum zinc, copper status and Cu/Zn ratio in overweight and obesity: associations with oxidative stress, adipokines, and cardiometabolic traits in adult women.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Immunometabolic Dysregulation in Female Obesity: Mechanistic Links to Ovarian Dysfunction, Implantation Failure, and Preeclampsia.Biomedicines · 2026Review
- Bioactive Phytochemicals fromNutrients · 2026Article
- In Vitro Investigation of the Toxicity Mechanisms of Antidepressant Drugs on Adipose Tissue in 3T3-L1 Cells.Journal of applied toxicology : JAT · 2026Article
- Effects of Boron on the Lipid Metabolism, Estradiol Concentration, Uterine Morphology and ERα Expression in Ovariectomized Rats.Biological trace element research · 2026Article
- The Influence of Statin Therapy on Markers of Endothelial Dysfunction, Endocan and Endoglin, in Postmenopausal Women-A Prospective Study.Biomedicines · 2026Article
- Real-World Evidence for Breast Cancer Risk Stratification: Insights from the P.I.N.K. Study.Cancers · 2026Article
- Longitudinal trends in general, central, and visceral adiposity indices among women with endometriosis: a population-based study.Journal of endocrinological investigation · 2026Article
- Influence of Biological Sex on Metabolic and Adipokine Responses after Metabolic-Bariatric Surgery: A Narrative Review.Current obesity reports · 2026Review
- Age-Metabolic Profile of Lower Serum Estradiol Among Women in Kazakhstan: A Large National Survey-Based Analytical Study.International journal of environmental research and public health · 2026Article
- Associations between waist-to-height ratio and hormonal-metabolic profiles in midlife women: evidence from a population-based cross-sectional study.Archives of gynecology and obstetrics · 2026Article
- Circulating METRNL, Adipocytokines, and Insulin-Resistance Markers After Repeated Whole-Body Cryotherapy in Women of Different Ages.International journal of molecular sciences · 2026Article
- The Anatomy of the Human Linea Alba: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2026Article
- Cold-Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans.Diabetes, obesity & metabolism · 2026Article
- Hormonal Shifts and Structural Strain: A Literature Review of Menopause and Perimenopause in Relation to Overuse Injuries and Stress Fractures.Annals of rehabilitation medicine · 2026Article
- Diabetes and cancer incidence among adults in the Hispanic Community Health Study/Study of Latinos.Cancer · 2026Article
- White adipose atrophy exacerbates cold stress and accelerates aging in male mice.Nature communications · 2026Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Menopause-related decline in estrogen levels is accompanied by a change in adipose tissue distribution from a gynoid to an android and an increased prevalence of obesity in women. These unfavorable phenomena can be partially restored by hormone replacement therapy, suggesting a significant role for estrogen in the regulation of adipocytes' function. Indeed, preclinical studies proved the involvement of these hormones in adipose tissue development, metabolism, and inflammatory activity. However, the relationship between estrogen and obesity is bidirectional. On the one hand-their deficiency leads to excessive fat accumulation and impairs adipocyte function, on the other-adipose tissue of obese individuals is characterized by altered expression of estrogen receptors and key enzymes involved in their synthesis. This narrative review aims to summarize the role of estrogen in adipose tissue development, physiology, and in obesity-related dysfunction. Firstly, the estrogen classification, synthesis, and modes of action are presented. Next, their role in regulating adipogenesis and adipose tissue activity in health and the course of obesity is described. Finally, the potential therapeutic applications of estrogen and its derivates in obesity treatment are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.