Evidence map›Paper›PMID 36979666›Full record

ArticleBiomedicines2023

The Third Dose of BNT162b2 COVID-19 Vaccine Does Not "Boost" Disease Flares and Adverse Events in Patients with Rheumatoid Arthritis.

Andrea Picchianti Diamanti, Assunta Navarra, Gilda Cuzzi, Alessandra Aiello, Simonetta Salemi, Roberta Di Rosa, Chiara De Lorenzo, Daniele Vio, Giandomenico Sebastiani, Mario Ferraioli and 12 more

Full text read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Andrea Picchianti DiamantiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.ORCID 0000-0002-8552-4641
Assunta NavarraTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00161 Rome, Italy.ORCID 0000-0002-3662-4312
Gilda CuzziTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00161 Rome, Italy.
Alessandra AielloTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00161 Rome, Italy.ORCID 0000-0003-2681-9383
Simonetta SalemiDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.
Roberta Di RosaDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.
Chiara De LorenzoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.
Daniele VioDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.
Giandomenico SebastianiDepartment of Rheumatology, San Camillo Hospital, 00152 Rome, Italy.ORCID 0000-0003-2969-6649
Mario FerraioliRheumatology, Allergology and Clinical Immunology, Department of 'Medicina dei Sistemi', University of Rome 'Tor Vergata', 00133 Rome, Italy.
Maurizio BenucciRheumatology Unit, S. Giovanni di Dio Hospital, Azienda USL-Toscana Centro, 50122 Florence, Italy.
Francesca Li GobbiRheumatology Unit, S. Giovanni di Dio Hospital, Azienda USL-Toscana Centro, 50122 Florence, Italy.
Fabrizio CantiniRheumatology Department, Hospital of Prato, 59100 Prato, Italy.
Vittoria PolidoriUOC Laboratorio Analisi e Biochimica Clinica, Sant'Andrea University Hospital, 00189 Rome, Italy.
Maurizio SimmacoUOC Laboratorio Analisi e Biochimica Clinica, Sant'Andrea University Hospital, 00189 Rome, Italy.
Esmeralda CialdiUOC Laboratorio Analisi e Biochimica Clinica, Sant'Andrea University Hospital, 00189 Rome, Italy.
Palma ScolieriUOC di Medicina e Rete Reumatologica, Ospedale Nuovo Regina Margherita, 00153 Rome, Italy.ORCID 0000-0002-2055-7282
Vincenzo BruzzeseUOC di Medicina e Rete Reumatologica, Ospedale Nuovo Regina Margherita, 00153 Rome, Italy.
Emanuele NicastriClinical Division of Infectious Diseases, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00161 Rome, Italy.ORCID 0000-0002-5606-8712
Raffaele D'AmelioDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.ORCID 0000-0003-0669-2629
Bruno LaganàDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, S. Andrea University Hospital, 00189 Rome, Italy.ORCID 0000-0003-2305-4063
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00161 Rome, Italy.ORCID 0000-0001-8360-4376

Funding

Italian Ministry of Health, by the European Union's Horizon 2020 research and innovation pro-gramme under EVA GLOBAL grant 871029
6 · The paper itself

Abstract

Data on the risk of adverse events (AEs) and disease flares in autoimmune rheumatic diseases (ARDs) after the third dose of COVID-19 vaccine are scarce. The aim of this multicenter, prospective study is to analyze the clinical and immunological safety of BNT162b2 vaccine in a cohort of rheumatoid arthritis (RA) patients followed-up from the first vaccine cycle to the third dose. The vaccine showed an overall good safety profile with no patient reporting serious AEs, and a low percentage of total AEs at both doses (40/78 (51.3%) and 13/47 (27.7%) patients after the second and third dose, respectively (

Indexed as

adverse eventsautoimmune rheumatic diseasesCOVID-19disease flareimmunogenicitySARS-CoV-2 vaccine

Identifiers

PMID36979666
PMCPMC10045021

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read45
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.