Evidence map›Paper›PMID 36979519›Full record

ReviewBiosensors2023

A Brief Review of Graphene-Based Biosensors Developed for Rapid Detection of COVID-19 Biomarkers.

Narendhar Chandrasekar, Ramachandran Balaji, Ramaswamy Sandeep Perala, Nik Zulkarnine Nik Humaidi, Kirubanandan Shanmugam, Ying-Chih Liao, Michael Taeyoung Hwang, Saravanan Govindaraju

Open access · goldFull text readReview
In one paragraph

Review in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Narendhar ChandrasekarDepartment of BioNano Technology, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-si 13120, Republic of Korea.ORCID 0000-0003-3276-0859
Ramachandran BalajiDepartment of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.
Ramaswamy Sandeep PeralaDepartment of BioNano Technology, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-si 13120, Republic of Korea.
Nik Zulkarnine Nik HumaidiDepartment of BioNano Technology, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-si 13120, Republic of Korea.ORCID 0000-0001-6980-403X
Kirubanandan ShanmugamSaveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602105, India.ORCID 0000-0002-3461-9958
Ying-Chih LiaoDepartment of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan.ORCID 0000-0001-9496-4190
Michael Taeyoung HwangDepartment of BioNano Technology, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-si 13120, Republic of Korea.
Saravanan GovindarajuDepartment of BioNano Technology, Gachon University, 1342 Seongnam-Daero, Sujeong-Gu, Seongnam-si 13120, Republic of Korea.ORCID 0000-0002-0411-9557
Gachon University · KRNational Taiwan University · TWSaveetha University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of mutated species of COVID-19 antigens has provided a strong impetus for identifying a cost-effective, rapid and facile strategy for identifying the viral loads in public places. The ever-changing genetic make-up of SARS-CoV-2 posts a significant challenfge for the research community to identify a robust mechanism to target, bind and confirm the presence of a viral load before it spreads. Synthetic DNA constructs are a novel strategy to design complementary DNA sequences specific for antigens of interest as in this review's case SARS-CoV-2 antigens. Small molecules, complementary DNA and protein-DNA complexes have been known to target analytes in minimal concentrations. This phenomenon can be exploited by nanomaterials which have unique electronic properties such as ballistic conduction. Graphene is one such candidate for designing a device with a very low LOD in the order of zeptomolar and attomolar concentrations. Surface modification will be the significant aspect of the device which needs to have a high degree of sensitivity at the same time as providing a rapid signaling mechanism.

Indexed as

Biosensing TechniquesCOVID-19GraphiteBiomarkersDNA, ComplementaryHumansSARS-CoV-2BiomarkersDNA, ComplementaryGraphiteantigenscomplementary DNACOVID-19protein–DNASARS

Identifiers

PMID36979519
PMCPMC10046683
OpenAlexW4321598408

What OpenQuestion holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.