Evidence map›Paper›PMID 36979504›Full record

ArticleBiomolecules2023

Oral Immunization with

Giovanni Sarnelli, Alessandro Del Re, Marcella Pesce, Jie Lu, Giovanni Esposito, Walter Sanseverino, Chiara Corpetti, Silvia Basili Franzin, Luisa Seguella, Irene Palenca and 4 more

Open access · goldFull text read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Natural carrier systems in cancer vaccines and immunotherapy.Human vaccines & immunotherapeutics · 2025
    Review
  4. Review
  5. Article
  6. Gut Microbiota-Based Immunotherapy: EngineeredMedicina (Kaunas, Lithuania) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Giovanni SarnelliDepartment of Clinical Medicine and Surgery, Section of Gastroenterology, University Federico II, 80138 Naples, Italy.ORCID 0000-0002-1467-1134
Alessandro Del ReDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Marcella PesceDepartment of Clinical Medicine and Surgery, Section of Gastroenterology, University Federico II, 80138 Naples, Italy.ORCID 0000-0001-5996-4259
Jie LuNextbiomics S.R.L. (Società a Responsabilità Limitata), 80100 Naples, Italy.ORCID 0000-0001-6843-9720
Giovanni EspositoNextbiomics S.R.L. (Società a Responsabilità Limitata), 80100 Naples, Italy.
Walter SanseverinoNextbiomics S.R.L. (Società a Responsabilità Limitata), 80100 Naples, Italy.ORCID 0000-0003-3324-5912
Chiara CorpettiDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Silvia Basili FranzinDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Luisa SeguellaDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-2346-9912
Irene PalencaDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-5019-653X
Sara RurgoDepartment of Clinical Medicine and Surgery, Section of Gastroenterology, University Federico II, 80138 Naples, Italy.
Fatima Domenica Elisa De PalmaDepartment of Molecular Medicine and Medical Biotechnologies, Centro Ingegneria Genetica-Biotecnologie Avanzate s.c.a rl, 80131 Naples, Italy.ORCID 0000-0002-6109-2768
Aurora ZilliDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University of Rome, 00185 Rome, Italy.
Giuseppe EspositoNextbiomics S.R.L. (Società a Responsabilità Limitata), 80100 Naples, Italy.ORCID 0000-0001-8080-8218
Sapienza University of Rome · ITTecnologie Avanzate (Italy) · ITFederico II University Hospital · ITChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As of October 2022, the COVID-19 pandemic continues to pose a major public health conundrum, with increased rates of symptomatic infections in vaccinated individuals. An ideal vaccine candidate for the prevention of outbreaks should be rapidly scalable, easy to administer, and able to elicit a potent mucosal immunity. Towards this aim, we proposed an engineered

Indexed as

COVID-19Spike Glycoprotein, CoronavirusAnimalsAntibodies, ViralAntibody FormationCOVID-19 VaccinesEscherichia coliHumansImmunizationMicePandemicsSARS-CoV-2Antibodies, ViralCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19engineered probioticsIgAoral vaccine

Identifiers

PMID36979504
PMCPMC10046078
OpenAlexW4328106153

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read61
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.