ArticleBiomolecules2023
Solid-State Preparation and Characterization of 2-Hydroxypropylcyclodextrins-Iodine Complexes as Stable Iodophors.
Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Caging Polyhalide Anions in Polycyclodextrin for Long-Lasting Aqueous Zinc-Iodine Batteries.Angewandte Chemie (International ed. in English) · 2026Article
- Transport of Molecular Iodine From Antiseptic Iodophors across Hydrophilic-lipophilic Interfaces: Influence of Phospholipids.ACS omega · 2025Article
- Evaluation of the Therapeutic Efficacy of the Newly Formulated Drug "Novostron" as an Experimental Basis for Clinical Trials.ACS omega · 2025Article
- Development of a γ-Cyclodextrin-Based Cryogel Loaded with Trimethoprim for Acne Treatment: Design, Synthesis, and In Vitro Evaluation.International journal of molecular sciences · 2025Article
- Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status.Drug delivery and translational research · 2025Review
- Thymol, a Monoterpenoid within Polymeric Iodophor Formulations and Their Antimicrobial Activities.International journal of molecular sciences · 2024Article
- Green Synthesized Polymeric Iodophors with Thyme as Antimicrobial Agents.International journal of molecular sciences · 2024Article
- Cyclodextrins as Drug Release Modulators and Toxic Compound Removal Agents.Biomolecules · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of iodine as antiseptic poses some issues related to its low water solubility and high volatility. Stable solid iodine-containing formulations are highly advisable and currently limited to the povidone-iodine complex. In this study, complexes of molecular iodine with 2-hydroxypropyl α-, β- and γ-cyclodextrins were considered water-soluble iodophors and prepared in a solid state by using three different methods (liquid-assisted grinding, co-evaporation and sealed heating). The obtained solids were evaluated for their iodine content and stability over time in different conditions using a fully validated UV method. The assessment of the actual formation of an inclusion complex in a solid state was carried out by thermal analysis, and the presence of iodine was further confirmed by SEM/EDX and XPS analyses. High levels of iodine content (8.3-10.8%) were obtained with all the tested cyclodextrins, and some influence was exerted by the employed preparation method. Potential use as solid iodophors can be envisaged for these iodine complexes, among which those with 2-hydroxypropyl-α-cyclodextrin were found the most stable, regardless of the preparation technique. The three prepared cyclodextrin-iodine complexes proved effective as bactericides against
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