Evidence map›Paper›PMID 36979381›Full record

ArticleBiomolecules2023

Residues of Legume AG41 Peptide Crucial to Its Bio-Insecticidal Activity.

Fatima Diya, Laurence Jouvensal, Isabelle Rahioui, Karine Loth, Catherine Sivignon, Lamis Karaki, Linda Kfoury, Francine Rizk, Pedro Da Silva

Open access · goldFull text read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Heliyon · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Fatima DiyaINSA-Lyon, INRA, BF2I, UMR0203, Université de Lyon, 69621 Villeurbanne, France.
Laurence JouvensalCentre de Biophysique Moléculaire, CNRS UPR 4301, 45071 Orléans, France.ORCID 0000-0001-9223-9286
Isabelle RahiouiINSA Lyon, INRAE, BF2I, UMR 203, Université de Lyon, 69621 Villeurbanne, France.
Karine LothCentre de Biophysique Moléculaire, CNRS UPR 4301, 45071 Orléans, France.ORCID 0000-0001-7058-8661
Catherine SivignonINSA Lyon, INRAE, BF2I, UMR 203, Université de Lyon, 69621 Villeurbanne, France.
Lamis KarakiDepartment of Biological and Chemical Sciences, Lebanese International University, Beirut P.O. Box 146404, Lebanon.
Linda KfouryPlant Protection Department, Faculty of Agronomy, Lebanese University, Dekwaneh P.O. Box 146404, Lebanon.
Francine RizkInnovative Therapeutic Laboratory, Branch II, Department of Life and Earth Sciences, Faculty of Sciences, Lebanese University, Beirut P.O. Box 146404, Lebanon.
Pedro Da SilvaINSA-Lyon, INRA, BF2I, UMR0203, Université de Lyon, 69621 Villeurbanne, France.
Université Claude Bernard Lyon 1 · FRLebanese University · LBUniversité d'Orléans · FRLebanese International University · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, crop protection relies heavily on chemical treatments, which ultimately leads to environmental contamination and pest resistance. Societal and public policy considerations urge the need for new eco-friendly solutions. In this perspective, biopesticides are effective alternatives to chemical insecticides for the control of various insect pests. Legumes contain numerous insecticidal proteins aimed at protecting their high nitrogen content from animal/insect predation. Investigating one such protein family at genome scale, we discovered a unique diversity of the albumin 1 family in the (model) barrel medic genome. Only some members retained very high insecticidal activity. We uncovered that AG41 peptide from the alfalfa roots displays an outstanding insecticidal activity against several pests such as aphids and weevils. Here we report the 3D structure and activity of AG41 peptide. Significant insights into the structural/functional relationships explained AG41 high insecticidal activity. Such observations pave the way for the development of bio-insecticides, with AG41 peptide as the lead compound.

Indexed as

FabaceaeInsecticidesAlbuminsAnimalsInsectaPeptidesAlbuminsInsecticidesPeptidesbio-insecticidal peptideknottin peptidelegume plantpeptide 3D structurestructure function relationships

Identifiers

PMID36979381
PMCPMC10046687
OpenAlexW4322504625

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read23
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.