Evidence map›Paper›PMID 36979261›Full record

ReviewBrain sciences2023

Noninvasive Brain Stimulation for Neurorehabilitation in Post-Stroke Patients.

Kun-Peng Li, Jia-Jia Wu, Zong-Lei Zhou, Dong-Sheng Xu, Mou-Xiong Zheng, Xu-Yun Hua, Jian-Guang Xu

Open access · goldFull text readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 7 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Systematic review: Resting state functional MRI as a biomarker for non-invasive brain stimulation in upper limb recovery post-stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  3. Non-invasive brain stimulation for treating visual defects: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  5. Comparative efficacy of different noninvasive brain stimulation protocols on upper-extremity motor function and activities of daily living after stroke: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kun-Peng LiSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jia-Jia WuCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Zong-Lei ZhouDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.
Dong-Sheng XuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Mou-Xiong ZhengDepartment of Traumatology and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Xu-Yun HuaDepartment of Traumatology and Orthopedics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Jian-Guang XuSchool of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0002-9405-5453
Shanghai University of Traditional Chinese Medicine · CNFudan University · CN

Funding

National Key R&D Program of China 2018YFC2001600, and 2018YFC2001604National Natural Science Foundation of China 81802249, 81871836, 81874035, and 81902301Shanghai Municipal Commission of Health and Family Planning 2018YQ02Shanghai Rising-Star Program 19QA1409000Shanghai Science and Technology Committee 22010504200Shanghai Youth Top Talent Development Plan, Shanghai "Rising Stars of Medical Talent" Youth Development Program, Program of Shanghai Academic Research Leader 19XD1403600
6 · The paper itself

Abstract

Characterized by high morbidity, mortality, and disability, stroke usually causes symptoms of cerebral hypoxia due to a sudden blockage or rupture of brain vessels, and it seriously threatens human life and health. Rehabilitation is the essential treatment for post-stroke patients suffering from functional impairments, through which hemiparesis, aphasia, dysphagia, unilateral neglect, depression, and cognitive dysfunction can be restored to various degrees. Noninvasive brain stimulation (NIBS) is a popular neuromodulatory technology of rehabilitation focusing on the local cerebral cortex, which can improve clinical functions by regulating the excitability of corresponding neurons. Increasing evidence has been obtained from the clinical application of NIBS, especially repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS). However, without a standardized protocol, existing studies on NIBS show a wide variation in terms of stimulation site, frequency, intensity, dosage, and other parameters. Its application for neurorehabilitation in post-stroke patients is still limited. With advances in neuronavigation technologies, functional near-infrared spectroscopy, and functional MRI, specific brain regions can be precisely located for stimulation. On the basis of our further understanding on neural circuits, neuromodulation in post-stroke rehabilitation has also evolved from single-target stimulation to co-stimulation of two or more targets, even circuits and the network. The present study aims to review the findings of current research, discuss future directions of NIBS application, and finally promote the use of NIBS in post-stroke rehabilitation.

Indexed as

noninvasive brain stimulationpost-strokerepetitive transcranial magnetic stimulationtranscranial direct current stimulationtranscranial focused ultrasound stimulationtranscutaneous vagus nerve stimulation

Identifiers

PMID36979261
PMCPMC10046557
OpenAlexW4323365161

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read17
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.