Evidence map›Paper›PMID 36979228›Full record

ArticleBrain sciences2023

TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation.

Giulia Pieramico, Roberto Guidotti, Aino E Nieminen, Antea D'Andrea, Alessio Basti, Victor H Souza, Jaakko O Nieminen, Pantelis Lioumis, Risto J Ilmoniemi, Gian Luca Romani and 2 more

Open access · goldFull text read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Multi-coil TMS for preclinical applications in ultra-high-field MRI.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Giulia PieramicoDepartment of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0009-0006-8183-1376
Roberto GuidottiDepartment of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-0807-6005
Aino E NieminenDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, 02150 Espoo, Finland.ORCID 0000-0002-6841-7043
Antea D'AndreaDepartment of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0001-9507-9505
Alessio BastiDepartment of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.
Victor H SouzaDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, 02150 Espoo, Finland.ORCID 0000-0002-0254-4322
Jaakko O NieminenDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, 02150 Espoo, Finland.
Pantelis LioumisDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, 02150 Espoo, Finland.ORCID 0000-0003-2016-9199
Risto J IlmoniemiDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, 02150 Espoo, Finland.
Gian Luca RomaniInstitute for Advanced Biomedical Technologies, University of Chieti-Pescara, 66100 Chieti, Italy.
Vittorio PizzellaDepartment of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-0452-1108
Laura MarzettiDepartment of Neuroscience, Imaging and Clinical Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-6481-3743
University of Chieti-Pescara · ITUniversity of Helsinki · FIUniversidade Federal de Juiz de Fora · BR

Funding

Academy of Finland 349985European Research Council 810377
6 · The paper itself

Abstract

Coregistration of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) allows non-invasive probing of brain circuits: TMS induces brain activation due to the generation of a properly oriented focused electric field (E-field) using a coil placed on a selected position over the scalp, while EEG captures the effects of the stimulation on brain electrical activity. Moreover, the combination of these techniques allows the investigation of several brain properties, including brain functional connectivity. The choice of E-field parameters, such as intensity, orientation, and position, is crucial for eliciting cortex-specific effects. Here, we evaluated whether and how the spatial pattern, i.e., topography and strength of functional connectivity, is modulated by the stimulus orientation. We systematically altered the E-field orientation when stimulating the left pre-supplementary motor area and showed an increase of functional connectivity in areas associated with the primary motor cortex and an E-field orientation-specific modulation of functional connectivity intensity.

Indexed as

functional connectivitystimulus orientationTMS-EEG

Identifiers

PMID36979228
PMCPMC10046030
OpenAlexW4322629104

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.