Evidence map›Paper›PMID 36979205›Full record

ArticleBrain sciences2023

Modulation Effects of Repeated Transcranial Direct Current Stimulation at the Dorsolateral Prefrontal Cortex: A Pulsed Continuous Arterial Spin Labeling Study.

Valeria Sacca, Nasim Maleki, Ya Wen, Sierra Hodges, Jian Kong

Open access · goldFull text read
In one paragraph

Article in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Valeria SaccaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 2nd Avenue, Charlestown, MA 02129, USA.ORCID 0000-0003-2497-8110
Nasim MalekiDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 2nd Avenue, Charlestown, MA 02129, USA.
Ya WenDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 2nd Avenue, Charlestown, MA 02129, USA.
Sierra HodgesDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 2nd Avenue, Charlestown, MA 02129, USA.ORCID 0000-0001-5145-5134
Jian KongDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 120 2nd Avenue, Charlestown, MA 02129, USA.
Harvard University · US

Funding

Neuromodulation of placebo and nocebo effectsR01AT008563 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2015 to 2019
$3.9M
NCCIH NIH HHS R01 AT008563NIH HHS R01AT008563
6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a promising non-invasive method to modulate brain excitability. The aim of this study was to better understand the cerebral blood flow (CBF) changes during and after repeated tDCS at the right dorsolateral prefrontal cortex (DLPFC) in healthy participants using pulsed continuous arterial spin labeling (pCASL). Elucidating CBF changes associated with repeated tDCS may shed light on the understanding of the mechanisms underlying the therapeutic effects of tDCS. tDCS was applied for three consecutive days for 20 min at 2 mA, and MRI scans were performed on day 1 and 3. During anodal tDCS, increased CBF was detected in the bilateral thalamus on day 1 and 3 (12% on day 1 and of 14% on day 3) and in the insula on day 1 (12%). After anodal tDCS on day 1, increased CBF was detected in the cerebellum and occipital lobe (11.8%), while both cathodal and sham tDCS were associated with increased CBF in the insula (11% and 10%, respectively). Moreover, anodal tDCS led to increased CBF in the lateral prefrontal cortex and midcingulate cortex in comparison to the sham. These findings suggest that tDCS can modulate the CBF and different tDCS modes may lead to different effects.

Indexed as

dorsolateral prefrontal cortex (DLPFC)lateral prefrontal cortex (LPFC)pulsed continuous arterial spin labeling (pCASL)transcranial direct current stimulation (tDCS)

Identifiers

PMID36979205
PMCPMC10046672
OpenAlexW4322486533

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read11
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.