Evidence map›Paper›PMID 36979085›Full record

ArticleBiology2023

Genetic Variants in Protein Tyrosine Phosphatase Non-Receptor Type 23 Are Responsible for Mesiodens Formation.

Ploy Adisornkanj, Rajit Chanprasit, Steven Eliason, Juan M Fons, Worrachet Intachai, Sissades Tongsima, Bjorn Olsen, Stefan T Arold, Chumpol Ngamphiw, Brad A Amendt and 2 more

Open access · goldFull text read
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Ploy AdisornkanjCenter of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0002-8096-8809
Rajit ChanprasitDental Department, Wiang Kaen Hospital, Wiang Kaen, Chiang Rai 57310, Thailand.
Steven EliasonDepartment of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA 52242, USA.
Juan M FonsCentre for Craniofacial and Regenerative Biology, King's College London, Floor 27 Guy' Hospital, London Bridge, London SE1 9RT, UK.ORCID 0000-0002-6044-1989
Worrachet IntachaiCenter of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Sissades TongsimaNational Biobank of Thailand, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani 12120, Thailand.
Bjorn OlsenDepartment of Developmental Biology, Harvard School of Dental Medicine, Harvard University, Boston, MA 02115, USA.
Stefan T AroldComputational Bioscience Research Center, Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.ORCID 0000-0001-5278-0668
Chumpol NgamphiwNational Biobank of Thailand, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani 12120, Thailand.ORCID 0000-0002-8581-397X
Brad A AmendtDepartment of Anatomy and Cell Biology and the Craniofacial Anomalies Research Center, The University of Iowa, Iowa City, IA 52242, USA.
Abigail S TuckerCentre for Craniofacial and Regenerative Biology, King's College London, Floor 27 Guy' Hospital, London Bridge, London SE1 9RT, UK.ORCID 0000-0001-8871-6094
Piranit KantaputraCenter of Excellence in Medical Genetics Research, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.ORCID 0000-0001-9841-0881
Chiang Mai University · THKing's College London · GBNational Science and Technology Development Agency · THUniversity of Iowa · USHarvard University · USUniversité de Montpellier · FR

Funding

Health Systems Research Institute 64-123King Abdullah University of Science and Technology FCC/1/1976-25
6 · The paper itself

Abstract

A mesiodens is a supernumerary tooth located in the midline of the premaxilla. To investigate the genetic cause of mesiodens, clinical and radiographic examination were performed on 23 family members of a two-generation Hmong family. Whole exome sequencing (WES) or Sanger sequencing were performed in 22 family members and two unrelated Thai patients with mesiodens. WES in the Hmong family revealed a missense mutation (c.1807G>A;p.Glu603Lys) in

Indexed as

extra toothmesiodentesmutationphosphataseprotein expressionPTPN23RNA expressionsupernumerary tooth

Identifiers

PMID36979085
PMCPMC10045488
OpenAlexW4323050767

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read37
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.