Evidence map›Paper›PMID 36978971›Full record

ReviewAntioxidants (Basel, Switzerland)2023

The Role of Seminal Oxidative Stress in Recurrent Pregnancy Loss.

Rhianna Davies, Channa N Jayasena, Raj Rai, Suks Minhas

Open access · goldFull text readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Rhianna DaviesDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.ORCID 0000-0001-6922-4553
Channa N JayasenaDepartment of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.
Raj RaiDepartment of Obstetrics and Gynaecology, St Mary's Hospital, Imperial College NHS Trust, London W2 1NY, UK.
Suks MinhasDepartment of Urology, Charing Cross Hospital, Imperial College NHS Trust, London W6 8RF, UK.
Imperial College London · GBCharing Cross Hospital · GBSt Mary's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent pregnancy loss is a distressing condition affecting 1-2% of couples. Traditionally investigations have focused on the female, however more recently researchers have started to explore the potential contribution of the male partner. Seminal reactive oxygen species have a physiological function in male reproduction but in excess are suspected to generate structural and functional damage to the sperm. Evidence is mounting to support an association between elevated seminal reaction oxygen species and recurrent pregnancy loss. Studies suggest that the rates of sperm DNA damage are higher in the male partners of women affected by recurrent pregnancy loss compared with unaffected men. However, the available pool of data is conflicting, and interpretation is limited by the recent change in nomenclature and the heterogeneity of study methodologies. Furthermore, investigation into the effects of oxidative stress on the epigenome show promise. The value of antioxidant therapy in the management of recurrent pregnancy loss currently remains unclear.

Indexed as

antioxidantsreactive oxygen speciesrecurrent pregnancy lossROSsperm DNA damage

Identifiers

PMID36978971
PMCPMC10045000
OpenAlexW4324358189

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read7
measurements read14
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.