Evidence map›Paper›PMID 36978945›Full record

ArticleAntioxidants (Basel, Switzerland)2023

In Silico and In Vitro Study of Antioxidant Potential of Urolithins.

Emanuela Marchese, Valentina Orlandi, Federica Turrini, Isabella Romeo, Raffaella Boggia, Stefano Alcaro, Giosuè Costa

Full text read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Development of a submicron emulsion-based delivery system to improve the anti-inflammatory activity of urolithin A.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025
    Article
  5. Article
  6. Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emanuela MarcheseDipartimento di Scienze della Salute, Università degli Studi "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0001-5701-0873
Valentina OrlandiDipartimento di Farmacia, Università degli Studi di Genova, Viale Cembrano 4, 16148 Genova, Italy.
Federica TurriniDipartimento di Farmacia, Università degli Studi di Genova, Viale Cembrano 4, 16148 Genova, Italy.ORCID 0000-0002-4973-0026
Isabella RomeoDipartimento di Scienze della Salute, Università degli Studi "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0002-5799-7863
Raffaella BoggiaDipartimento di Farmacia, Università degli Studi di Genova, Viale Cembrano 4, 16148 Genova, Italy.ORCID 0000-0002-7043-4555
Stefano AlcaroDipartimento di Scienze della Salute, Università degli Studi "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.
Giosuè CostaDipartimento di Scienze della Salute, Università degli Studi "Magna Græcia" di Catanzaro, Campus "S. Venuta", Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0003-0947-9479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, quantum chemical calculations based on density functional theory (DFT) were performed to predict the antioxidant potential of four bioactive gut microbiota metabolites of the natural polyphenols ellagitannins (ETs) and ellagic acid (EA), also known as urolithins (UROs). In order to evaluate their ability to counter the effect of oxidative stress caused by reactive oxygen species (ROS), such as the hydroperoxyl radical (

Indexed as

antioxidant mechanismDFTDPPHFRAPkinetic constantsradical scavengingurolithins

Identifiers

PMID36978945
PMCPMC10045577

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read23
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.