Evidence map›Paper›PMID 36978869›Full record

ArticleAntioxidants (Basel, Switzerland)2023

High Concentration of Protein Oxidation Biomarker O-Tyr/Phe Predicts Better Outcome in Childhood Bacterial Meningitis.

Emilie Rugemalira, Irmeli Roine, Julia Kuligowski, Ángel Sánchez-Illana, José David Piñeiro-Ramos, Sture Andersson, Manuel Leite Cruzeiro, Máximo Vento, Tuula Pelkonen

Open access · goldFull text read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Emilie RugemaliraChildren's Hospital, Pediatric Research Center, Helsinki University Hospital, Stenbäckinkatu 9, 00029 Helsinki, Finland.
Irmeli RoineFaculty of Medicine, University Diego Portales, Avenida Manuel Rodríguez Sur 343, Santiago 8370109, Chile.ORCID 0000-0003-0020-361X
Julia KuligowskiHealth Research Institute La Fe (IISLAFE), Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain.ORCID 0000-0001-6979-2235
Ángel Sánchez-IllanaHealth Research Institute La Fe (IISLAFE), Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain.ORCID 0000-0001-7630-0614
José David Piñeiro-RamosHealth Research Institute La Fe (IISLAFE), Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain.ORCID 0000-0003-1628-9075
Sture AnderssonChildren's Hospital, Pediatric Research Center, Helsinki University Hospital, Stenbäckinkatu 9, 00029 Helsinki, Finland.
Manuel Leite CruzeiroHospital Pediátrico David Bernardino, Rua Amilcar Cabral, Luanda, Angola.
Máximo VentoHealth Research Institute La Fe (IISLAFE), Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain.ORCID 0000-0003-0061-4742
Tuula PelkonenChildren's Hospital, Pediatric Research Center, Helsinki University Hospital, Stenbäckinkatu 9, 00029 Helsinki, Finland.
University of Helsinki · FIInstituto de Investigación Sanitaria La Fe · ESClínica Sagrada Esperança · AOHospital Universitari i Politècnic La Fe · ESUniversidad Diego Portales · CLUniversitat de València · ES

Funding

Helsinki Children's Hospital N/ALastentautien Tutkimussäätiö N/A
6 · The paper itself

Abstract

Neuronal damage in bacterial meningitis (BM) partly stems from the host´s inflammatory response and induced oxidative stress (OS). We studied the association of cerebrospinal fluid (CSF) biomarkers indicating oxidative damage to proteins with course of illness and outcome in childhood BM in Angola. Ortho-tyrosine/phenylalanine (o-Tyr/Phe), 3-chlorotyrosine/para-tyrosine (3Cl-Tyr/p-Tyr), and 3-nitrotyrosine/para-tyrosine (3NO

Indexed as

biomarkerchildrenortho-tyrosineoxidative stressprotein oxidation

Identifiers

PMID36978869
PMCPMC10045379
OpenAlexW4323047264

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read31
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.